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Effect of Platelet-Rich Plasma on Nonsurgically Treated Acute Achilles Tendon Ruptures: A Randomized, Double-Blinded Prospective Study.
Boesen, Anders Ploug; Boesen, Morten Ilum; Hansen, Rudi; Barfod, Kristoffer Weisskirchner; Lenskjold, Anders; Malliaras, Peter; Langberg, Henning.
Afiliación
  • Boesen AP; Institute of Sports Medicine, Department of Orthopaedic Surgery M, Bispebjerg Hospital, Copenhagen, Denmark.
  • Boesen MI; Center for Healthy Aging, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Hansen R; Department of Orthopaedic Surgery, Hvidovre Hospital, Hvidovre, Denmark.
  • Barfod KW; Department Of Orthopaedics, Køge Sygehus, Køge, Denmark.
  • Lenskjold A; Institute of Sports Medicine, Department of Orthopaedic Surgery M, Bispebjerg Hospital, Copenhagen, Denmark.
  • Malliaras P; Center for Healthy Aging, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Langberg H; Department of Orthopaedic Surgery, Hvidovre Hospital, Hvidovre, Denmark.
Am J Sports Med ; 48(9): 2268-2276, 2020 07.
Article en En | MEDLINE | ID: mdl-32485112
BACKGROUND: An acute Achilles tendon rupture (ATR) is a long-lasting and devastating injury. Possible biological augmentation to promote and strengthen tendon healing after an ATR would be desirable. PURPOSE: To determine whether the application of a platelet-rich plasma (PRP) injection in nonsurgically treated ATRs may promote healing and thereby improve functional outcomes. STUDY DESIGN: Randomized controlled trial; Level of evidence, 2. METHODS: A total of 40 men (aged 18-60 years) with an ATR incurred within 72 hours were included, and 38 were followed for 12 months. All patients were treated with an orthosis with 3 wedges for 8 weeks; full weightbearing from day 1 was allowed, combined with either 4 PRP or 4 placebo injections (a few drops of saline, <0.5 mL, under the skin) 14 days apart. All patients received the same instructions on an exercise program starting from week 9. Outcomes included the self-reported Achilles tendon Total Rupture Score (ATRS) as well as heel-rise work, heel-rise height, tendon elongation, calf circumference, and ankle dorsiflexion range of motion. RESULTS: The mean ATRS score improved in both groups at all time points (P < .001), but there was no difference between the groups at any time points (12 months: 90.1 points in PRP group and 88.8 points in placebo group). No differences in all functional outcomes at any time points were seen between the groups. At 12 months, the injured leg did not reach normal functional values compared with the uninjured leg. CONCLUSION: The application of PRP in nonsurgically treated ATRs did not appear to show any superior clinical and functional improvement. REGISTRATION: NCT02417922 (ClinicalTrials.gov identifier).
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Rotura / Tendón Calcáneo / Traumatismos de los Tendones / Plasma Rico en Plaquetas Tipo de estudio: Clinical_trials / Observational_studies / Prognostic_studies Límite: Adolescent / Adult / Humans / Male / Middle aged Idioma: En Revista: Am J Sports Med Año: 2020 Tipo del documento: Article País de afiliación: Dinamarca Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Rotura / Tendón Calcáneo / Traumatismos de los Tendones / Plasma Rico en Plaquetas Tipo de estudio: Clinical_trials / Observational_studies / Prognostic_studies Límite: Adolescent / Adult / Humans / Male / Middle aged Idioma: En Revista: Am J Sports Med Año: 2020 Tipo del documento: Article País de afiliación: Dinamarca Pais de publicación: Estados Unidos