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Absorption and Disposition of Coproporphyrin I (CPI) in Cynomolgus Monkeys and Mice: Pharmacokinetic Evidence to Support the Use of CPI to Inform the Potential for Organic Anion-Transporting Polypeptide Inhibition.
Gu, Xiaomei; Wang, Lifei; Gan, Jinping; Fancher, R Marcus; Tian, Yuan; Hong, Yang; Lai, Yurong; Sinz, Michael; Shen, Hong.
Afiliación
  • Gu X; Departments of Metabolism and Pharmacokinetics (X.G., L.W., J.G., R.M.F., Y.L., M.S., H.S.) and Radiochemistry (Y.T., Y.H.), Bristol Myers Squibb Company, Princeton, New Jersey.
  • Wang L; Departments of Metabolism and Pharmacokinetics (X.G., L.W., J.G., R.M.F., Y.L., M.S., H.S.) and Radiochemistry (Y.T., Y.H.), Bristol Myers Squibb Company, Princeton, New Jersey.
  • Gan J; Departments of Metabolism and Pharmacokinetics (X.G., L.W., J.G., R.M.F., Y.L., M.S., H.S.) and Radiochemistry (Y.T., Y.H.), Bristol Myers Squibb Company, Princeton, New Jersey.
  • Fancher RM; Departments of Metabolism and Pharmacokinetics (X.G., L.W., J.G., R.M.F., Y.L., M.S., H.S.) and Radiochemistry (Y.T., Y.H.), Bristol Myers Squibb Company, Princeton, New Jersey.
  • Tian Y; Departments of Metabolism and Pharmacokinetics (X.G., L.W., J.G., R.M.F., Y.L., M.S., H.S.) and Radiochemistry (Y.T., Y.H.), Bristol Myers Squibb Company, Princeton, New Jersey.
  • Hong Y; Departments of Metabolism and Pharmacokinetics (X.G., L.W., J.G., R.M.F., Y.L., M.S., H.S.) and Radiochemistry (Y.T., Y.H.), Bristol Myers Squibb Company, Princeton, New Jersey hong.shen1@bms.com.
  • Lai Y; Departments of Metabolism and Pharmacokinetics (X.G., L.W., J.G., R.M.F., Y.L., M.S., H.S.) and Radiochemistry (Y.T., Y.H.), Bristol Myers Squibb Company, Princeton, New Jersey.
  • Sinz M; Departments of Metabolism and Pharmacokinetics (X.G., L.W., J.G., R.M.F., Y.L., M.S., H.S.) and Radiochemistry (Y.T., Y.H.), Bristol Myers Squibb Company, Princeton, New Jersey.
  • Shen H; Departments of Metabolism and Pharmacokinetics (X.G., L.W., J.G., R.M.F., Y.L., M.S., H.S.) and Radiochemistry (Y.T., Y.H.), Bristol Myers Squibb Company, Princeton, New Jersey hong.shen1@bms.com.
Drug Metab Dispos ; 48(8): 724-734, 2020 08.
Article en En | MEDLINE | ID: mdl-32482623
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Coproporfirinas / Transportador 1 de Anión Orgánico Específico del Hígado Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Drug Metab Dispos Asunto de la revista: FARMACOLOGIA Año: 2020 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Coproporfirinas / Transportador 1 de Anión Orgánico Específico del Hígado Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Drug Metab Dispos Asunto de la revista: FARMACOLOGIA Año: 2020 Tipo del documento: Article Pais de publicación: Estados Unidos