Forced degradation studies of medroxyprogesterone acetate injectable suspensions (150â¯mg/ml) with implementation of HPLC, mass spectrometry, and QSAR techniques.

Jenkins, David; Harmon, Christopher L; Jia, Xiao; Kesselring, Allen; Hatcher, Danielle; Grayson, Katie; Ayres, Jennifer

Forced degradation studies of medroxyprogesterone acetate injectable suspensions (150â¯mg/ml) with implementation of HPLC, mass spectrometry, and QSAR techniques.

Jenkins, David; Harmon, Christopher L; Jia, Xiao; Kesselring, Allen; Hatcher, Danielle; Grayson, Katie; Ayres, Jennifer.

Afiliación

Jenkins D; Product Quality and Compliance, FHI 360, 2810 Meridian Parkway, Suite 160, Durham, NC 27713, USA. Electronic address: DJenkins@fhi360.org.
Harmon CL; Product Development and Introduction, FHI 360, 359 Blackwell Street, Suite 200, Durham, NC 27701, USA. Electronic address: CHarmon@fhi360.org.
Jia X; EKG Life Science Solutions, 4633 World Parkway Circle, St. Louis, MO 63134, USA. Electronic address: xjia@ekglabs.com.
Kesselring A; EKG Life Science Solutions, 4633 World Parkway Circle, St. Louis, MO 63134, USA. Electronic address: akesselring@ekglabs.com.
Hatcher D; EKG Life Science Solutions, 4633 World Parkway Circle, St. Louis, MO 63134, USA. Electronic address: dhatcher@ekglabs.com.
Grayson K; EKG Life Science Solutions, 4633 World Parkway Circle, St. Louis, MO 63134, USA. Electronic address: kgrayson@ekglabs.com.
Ayres J; Product Development and Introduction, FHI 360, 359 Blackwell Street, Suite 200, Durham, NC 27701, USA. Electronic address: jayres@fhi360.org.

J Pharm Biomed Anal ; 187: 113352, 2020 Aug 05.

Article en En | MEDLINE | ID: mdl-32480200

Asunto(s)

Cromatografía Líquida de Alta Presión/métodos; Agentes Anticonceptivos Hormonales/análisis; Espectrometría de Masas/métodos; Acetato de Medroxiprogesterona/análisis; Agentes Anticonceptivos Hormonales/efectos adversos; Agentes Anticonceptivos Hormonales/química; Contaminación de Medicamentos/prevención & control; Estabilidad de Medicamentos; Almacenaje de Medicamentos; Inyecciones; Acetato de Medroxiprogesterona/efectos adversos; Acetato de Medroxiprogesterona/química; Relación Estructura-Actividad Cuantitativa; Suspensiones

Palabras clave

Forced degradation; HPLC-MS/MS; Medroxyprogesterone acetate; Quantitative structure activity relationships; Toxicity risk

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Espectrometría de Masas / Cromatografía Líquida de Alta Presión / Acetato de Medroxiprogesterona / Agentes Anticonceptivos Hormonales Idioma: En Revista: J Pharm Biomed Anal Año: 2020 Tipo del documento: Article Pais de publicación: Reino Unido

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