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Local staging of prostate cancer with multiparametric-MRI: accuracy and inter-reader agreement.
Popita, Cristian; Popita, Anca-Raluca; Andrei, Adina; Rusu, Adriana; Petrut, Bogdan; Kacso, Gabriel; Bungardean, Catalina; Bolog, Nicolae; Coman, Ioan.
Afiliación
  • Popita C; Radiology Department, Ion Chiricuta Oncology Institute, Cluj-Napoca, Romania.
  • Popita AR; Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
  • Andrei A; Radiology Department, Ion Chiricuta Oncology Institute, Cluj-Napoca, Romania.
  • Rusu A; Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
  • Petrut B; Radiology Department, Emergency Children's Hospital, Cluj-Napoca, Romania.
  • Kacso G; Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
  • Bungardean C; Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
  • Bolog N; Urology Department, Ion Chiricuta Oncology Institute, Cluj-Napoca, Romania.
  • Coman I; Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
Med Pharm Rep ; 93(2): 150-161, 2020 Apr.
Article en En | MEDLINE | ID: mdl-32478321
BACKGROUND: The accuracy of prostate cancer local staging at the time of diagnosis directly influences patient prognosis and treatment. AIM: To evaluate the diagnostic performance and interobserver variability of mp-MRI in local staging of prostate cancer, using the histopathologic findings at prostatectomy as the reference standard. METHODS: Fifty patients (mean age 64.4±7.2) with biopsy confirmed prostate cancer were included in this prospective study. All patients were examined with mp-MRI before radical prostatectomy and images were read by three independent radiologists. Sensitivity (Se), specificity (Sp), positive predictive value (PPV), negative predictive value (NPV), and accuracy rate were calculated and compared for all three readers. Interobserver agreement was evaluated using Kappa Cohen coefficient of agreement. RESULTS: The overall Se, Sp, PPV, NPV and accuracy rates for detecting extraprostatic tumor extension (EPE) ranged between 76.5-94.1%, 45.5-84.9%, 43.8-76.2%, 83.3-96.6% and 58-88%. For evaluation of seminal vesicle invasion (SVI), the overall Se, Sp, PPV, NPV and accuracy rates ranged between 57.1-85.7%, 86.1-97.7%, 40.0-85.7%, 92.5-97.7% and 82-96%, respectively. The overall Kappa Cohen coefficient of agreement varied between 0.349-0.638 for EPE and between 0.507-0.668 for SVI. CONCLUSIONS: Our results showed that 1.5T mp-MRI is a reliable method for local staging of prostate cancer, with good diagnostic performance in detecting EPE and SVI. The overall interobserver agreement rates between readers with the same level of experience in prostate MRI ranged from fair to good in the evaluation of EPE and from moderate to good for the assessment of SVI.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Idioma: En Revista: Med Pharm Rep Año: 2020 Tipo del documento: Article País de afiliación: Rumanía Pais de publicación: Rumanía
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Idioma: En Revista: Med Pharm Rep Año: 2020 Tipo del documento: Article País de afiliación: Rumanía Pais de publicación: Rumanía