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Pharmacological STING Activation Is a Potential Alternative to Overcome Drug-Resistance in Melanoma.
Chipurupalli, Sandhya; Ganesan, Raja; Dhanabal, S P; Kumar, M Suresh; Robinson, Nirmal.
Afiliación
  • Chipurupalli S; Cellular-Stress and Immune Response Laboratory, Center for Cancer Biology, University of South Australia, Adelaide, SA, Australia.
  • Ganesan R; Department of Pharmacology, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Ooty, India.
  • Dhanabal SP; Cellular-Stress and Immune Response Laboratory, Center for Cancer Biology, University of South Australia, Adelaide, SA, Australia.
  • Kumar MS; TIFAC CORE in Herbal Drugs, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Ooty, India.
  • Robinson N; TIFAC CORE in Herbal Drugs, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Ooty, India.
Front Oncol ; 10: 758, 2020.
Article en En | MEDLINE | ID: mdl-32477956
Melanoma is the most aggressive type of skin cancer and resistance to the conventional chemotherapy is the major cause for its poor prognosis. Metabolic perturbations leading to increased production of reactive oxygen species activate NRF2-dependent anti-oxidative responses to survive oxidative stress. This protective function of NRF2 is the primary cause for therapy resistance in cancer as anti-cancer agents such as BRAF inhibitors also induce NRF2-dependent antioxidative response. We had reported that type I interferons produced upon activation of STING, abrogates NRF2 function. Therefore, we investigated if STING agonists such as the newly developed dimeric aminobenzimidazole (diABZI) could sensitize melanoma cells to the clinically used BRAF inhibitors. Our results reveal that pharmacological activation of STING by diABZI, down regulates NRF2-dependent anti-oxidative responses and potentiates cell-death in melanoma cells when used in combination with BRAF inhibitors.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Oncol Año: 2020 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Oncol Año: 2020 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Suiza