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Bcl6 Preserves the Suppressive Function of Regulatory T Cells During Tumorigenesis.
Li, Yiding; Wang, Zhiming; Lin, Huayu; Wang, Lisha; Chen, Xiangyu; Liu, Qiao; Zuo, Qianfei; Hu, Jianjun; Wang, Haoqiang; Guo, Junyi; Xie, Luoyingzi; Tang, Jianfang; Li, Zhirong; Hu, Li; Xu, Litian; Zhou, Xinyuan; Ye, Lilin; Huang, Qizhao; Xu, Lifan.
Afiliación
  • Li Y; Institute of Immunology, Third Military Medical University, Chongqing, China.
  • Wang Z; Institute of Immunology, Third Military Medical University, Chongqing, China.
  • Lin H; Institute of Immunology, Third Military Medical University, Chongqing, China.
  • Wang L; Institute of Immunology, Third Military Medical University, Chongqing, China.
  • Chen X; Institute of Immunology, Third Military Medical University, Chongqing, China.
  • Liu Q; Institute of Immunology, Third Military Medical University, Chongqing, China.
  • Zuo Q; Institute of Immunology, Third Military Medical University, Chongqing, China.
  • Hu J; Department of Oncology, Southwest Hospital, Third Military Medical University, Chongqing, China.
  • Wang H; Cancer Center, The General Hospital of Southern Theater Command, Guangzhou, China.
  • Guo J; Guanghua School of Stomatology, Guangdong Provincial Key Laboratory of Stomatology, Stomatological Hospital, Sun Yat-sen University, Guangzhou, China.
  • Xie L; Institute of Immunology, Third Military Medical University, Chongqing, China.
  • Tang J; Institute of Immunology, Third Military Medical University, Chongqing, China.
  • Li Z; Institute of Immunology, Third Military Medical University, Chongqing, China.
  • Hu L; Institute of Immunology, Third Military Medical University, Chongqing, China.
  • Xu L; Department of Gastrointestinal Surgery, The Fifth General Hospital of Kunming, Kunming, China.
  • Zhou X; Institute of Immunology, Third Military Medical University, Chongqing, China.
  • Ye L; Institute of Immunology, Third Military Medical University, Chongqing, China.
  • Huang Q; Cancer Center, The General Hospital of Western Theater Command, Chengdu, China.
  • Xu L; Institute of Immunology, Third Military Medical University, Chongqing, China.
Front Immunol ; 11: 806, 2020.
Article en En | MEDLINE | ID: mdl-32477338
During tumorigenesis, tumor infiltrating regulatory T (Treg) cells restrict the function of effector T cells in tumor microenvironment and thereby promoting tumor growth. The anti-tumor activity of effector T cells can be therapeutically unleashed, and is now being exploited for the treatment of various types of human cancers. However, the immune suppressive function of Treg cells remains a major hurdle to broader effectiveness of tumor immunotherapy. In this article, we reported that the deletion of Bcl6 specifically in Treg cells led to stunted tumor growth, which was caused by impaired Treg cell responses. Notably, Bcl6 is essential in maintaining the lineage stability of Treg cells in tumor microenvironment. Meanwhile, we found that the absence of follicular regulatory T (Tfr) cells, which is a result of Bcl6 deletion in Foxp3+ cells, was dispensable for tumor control. Importantly, the increased Bcl6 expression in Treg cells is associated with poor prognosis of human colorectal cancer and lymph node metastasis of skin melanoma. Furthermore, Bcl6 deletion in Treg cells exhibits synergistic effects with immune checkpoint blockade therapy. Collectively, these results indicate that Bcl6 actively participates in regulating Treg cell immune responses during tumorigenesis and can be exploited as a therapeutic target of anti-tumor immunity.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Cutáneas / Neoplasias Colorrectales / Linfocitos Infiltrantes de Tumor / Linfocitos T Reguladores / Proteínas Proto-Oncogénicas c-bcl-6 / Carcinogénesis / Inmunidad / Melanoma Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans / Male Idioma: En Revista: Front Immunol Año: 2020 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Cutáneas / Neoplasias Colorrectales / Linfocitos Infiltrantes de Tumor / Linfocitos T Reguladores / Proteínas Proto-Oncogénicas c-bcl-6 / Carcinogénesis / Inmunidad / Melanoma Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans / Male Idioma: En Revista: Front Immunol Año: 2020 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza