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Introducing of potent cytotoxic novel 2-(aroylamino)cinnamamide derivatives against colon cancer mediated by dual apoptotic signal activation and oxidative stress.
Omar, Abdelsattar M; El-Araby, Moustafa E; Abdelghany, Tamer M; Safo, Martin K; Ahmed, Mostafa H; Boothello, Rio; Patel, Bhaumik B; Abdel-Bakky, Mohamed S; Malebari, Azizah M; Ahmed, Hany E A; Elhaggar, Radwan S.
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  • Omar AM; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Al-Azhar University, Cairo 11884, Egypt. Electronic address: asmansour@kau.edu.sa.
  • El-Araby ME; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
  • Abdelghany TM; Department of Pharmacology, Faculty of Pharmacy, Al-Azhar University, Cairo 11884, Egypt.
  • Safo MK; Department of Medicinal Chemistry, and the Institute for Structural Biology, Drug Discovery and Development, School of Pharmacy, Virginia Commonwealth University, Richmond, VA 23298, USA.
  • Ahmed MH; Department of Medicinal Chemistry, and the Institute for Structural Biology, Drug Discovery and Development, School of Pharmacy, Virginia Commonwealth University, Richmond, VA 23298, USA.
  • Boothello R; Division of Hematology and Oncology, Department of Medicine, Virginia Commonwealth University, and Massey Cancer Center, Richmond, VA 23298. USA; Hunter Holmes McGuire VA Medical Center, Richmond, VA 23249, USA.
  • Patel BB; Division of Hematology and Oncology, Department of Medicine, Virginia Commonwealth University, and Massey Cancer Center, Richmond, VA 23298. USA; Hunter Holmes McGuire VA Medical Center, Richmond, VA 23249, USA.
  • Abdel-Bakky MS; Department of Pharmacology, Faculty of Pharmacy, Al-Azhar University, Cairo 11884, Egypt.
  • Malebari AM; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
  • Ahmed HEA; Pharmacognosy and Pharmaceutical Chemistry, College of Pharmacy, Taibah University, Al-Madinah Al-Munawarah 47114, Saudi Arabia; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Al-Azhar University, Cairo 11884, Egypt. Electronic address: heahmad@taibahu.edu.sa.
  • Elhaggar RS; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Helwan University, Cairo 11790, Egypt.
Bioorg Chem ; 101: 103953, 2020 08.
Article en En | MEDLINE | ID: mdl-32474179
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cinamatos / Apoptosis / Neoplasias del Colon / Estrés Oxidativo / Antineoplásicos Límite: Humans Idioma: En Revista: Bioorg Chem Año: 2020 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cinamatos / Apoptosis / Neoplasias del Colon / Estrés Oxidativo / Antineoplásicos Límite: Humans Idioma: En Revista: Bioorg Chem Año: 2020 Tipo del documento: Article Pais de publicación: Estados Unidos