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Features of COVID-19 post-infectious cytokine release syndrome in children presenting to the emergency department.
Waltuch, Temima; Gill, Prakriti; Zinns, Lauren E; Whitney, Rachel; Tokarski, Julia; Tsung, James W; Sanders, Jennifer E.
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  • Waltuch T; Department of Emergency Medicine, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place New York, New York, 11029, United States of America. Electronic address: timi.waltuch@gmail.com.
  • Gill P; Department of Emergency Medicine, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place New York, New York, 11029, United States of America. Electronic address: Prakriti.Gill@mountsinai.org.
  • Zinns LE; Department of Emergency Medicine, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place New York, New York, 11029, United States of America. Electronic address: Lauren.Zinns@mountsinai.org.
  • Whitney R; Department of Emergency Medicine, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place New York, New York, 11029, United States of America. Electronic address: Rachel.Whitney@mountsinai.org.
  • Tokarski J; Department of Emergency Medicine, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place New York, New York, 11029, United States of America. Electronic address: julie.tokarski@mountsinai.org.
  • Tsung JW; Department of Emergency Medicine, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place New York, New York, 11029, United States of America. Electronic address: james.tsung@mountsinai.org.
  • Sanders JE; Department of Emergency Medicine, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place New York, New York, 11029, United States of America. Electronic address: jennifer.sanders@mountsinai.org.
Am J Emerg Med ; 38(10): 2246.e3-2246.e6, 2020 Oct.
Article en En | MEDLINE | ID: mdl-32471782
The 2019 coronavirus disease (COVID-19) has not appeared to affect children as severely as adults. However, approximately 1 month after the COVID-19 peak in New York City in April 2020, cases of children with prolonged fevers abruptly developing inflammatory shock-like states have been reported in Western Europe and the United States. This case series describes four previously healthy children with COVID-19 infection confirmed by serologic antibody testing, but negative by nasopharyngeal RT-PCR swab, presenting to the Pediatric Emergency Department (PED) with prolonged fever (5 or more days) and abrupt onset of hemodynamic instability with elevated serologic inflammatory markers and cytokine levels (IL-6, IL-8 and TNF-α). Emergency physicians must maintain a high clinical suspicion for this COVID-19 associated post-infectious cytokine release syndrome, with features that overlap with Kawasaki Disease (KD) and Toxic Shock Syndrome (TSS) in children with recent or current COVID-19 infection, as patients can decompensate quickly.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Síndrome de Respuesta Inflamatoria Sistémica / COVID-19 Tipo de estudio: Diagnostic_studies Límite: Adolescent / Child / Child, preschool / Female / Humans / Male Idioma: En Revista: Am J Emerg Med Año: 2020 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Síndrome de Respuesta Inflamatoria Sistémica / COVID-19 Tipo de estudio: Diagnostic_studies Límite: Adolescent / Child / Child, preschool / Female / Humans / Male Idioma: En Revista: Am J Emerg Med Año: 2020 Tipo del documento: Article Pais de publicación: Estados Unidos