MDM2 phosphorylation mediates H<sub>2</sub>O<sub>2</sub>-induced lens epithelial cells apoptosis and age-related cataract.

Wang, Zhongying; Su, Dongmei; Sun, Zhaoyi; Liu, Shanhe; Sun, Lei; Li, Qian; Guan, Lina; Liu, Yong; Ma, Xu; Hu, Shanshan

MDM2 phosphorylation mediates H₂O₂-induced lens epithelial cells apoptosis and age-related cataract.

Wang, Zhongying; Su, Dongmei; Sun, Zhaoyi; Liu, Shanhe; Sun, Lei; Li, Qian; Guan, Lina; Liu, Yong; Ma, Xu; Hu, Shanshan.

Afiliación

Wang Z; Mudanjiang Medical College, Mudanjiang, 157011, Heilongjiang, China.
Su D; Department of Genetics, National Research Institute for Family Planning, Health Department, Beijing, 100081, China; Graduate School, Peking Union Medical College, Beijing, 100081, China.
Sun Z; Hongqi Hospital of Mudanjiang Medical College, Mudanjiang, 157011, Heilongjiang, China.
Liu S; Mudanjiang Medical College, Mudanjiang, 157011, Heilongjiang, China.
Sun L; Hongqi Hospital of Mudanjiang Medical College, Mudanjiang, 157011, Heilongjiang, China.
Li Q; Department of Genetics, National Research Institute for Family Planning, Health Department, Beijing, 100081, China.
Guan L; Department of Genetics, National Research Institute for Family Planning, Health Department, Beijing, 100081, China.
Liu Y; Medical Research Center of Mudanjiang Medical College, Mudanjiang, 157011, Heilongjiang, China.
Ma X; Department of Genetics, National Research Institute for Family Planning, Health Department, Beijing, 100081, China; Graduate School, Peking Union Medical College, Beijing, 100081, China. Electronic address: jswkysgc@126.com.
Hu S; Hongqi Hospital of Mudanjiang Medical College, Mudanjiang, 157011, Heilongjiang, China. Electronic address: hushanshan19830219@126.com.

Biochem Biophys Res Commun ; 528(1): 112-119, 2020 07 12.

Article en En | MEDLINE | ID: mdl-32471716

Asunto(s)

Envejecimiento/patología; Apoptosis; Catarata/patología; Células Epiteliales/metabolismo; Células Epiteliales/patología; Peróxido de Hidrógeno/toxicidad; Cristalino/patología; Proteínas Proto-Oncogénicas c-mdm2/metabolismo; Apoptosis/efectos de los fármacos; Línea Celular; Células Epiteliales/efectos de los fármacos; Femenino; Humanos; Masculino; Persona de Mediana Edad; Fosforilación/efectos de los fármacos; Fosfoserina/metabolismo; Proteínas Proto-Oncogénicas c-akt/metabolismo; Transducción de Señal

Palabras clave

Age-related cataract; Apoptosis; Lens epithelial cells; MDM2; Phosphorylation

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Catarata / Envejecimiento / Apoptosis / Células Epiteliales / Proteínas Proto-Oncogénicas c-mdm2 / Peróxido de Hidrógeno / Cristalino Tipo de estudio: Clinical_trials / Prognostic_studies Límite: Female / Humans / Male / Middle aged Idioma: En Revista: Biochem Biophys Res Commun Año: 2020 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos

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