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Cocaine has some effect on neuromedin U expressing neurons related to the brain reward system.
Anan, Madoka; Higa, Ryoko; Shikano, Kenshiro; Shide, Masahito; Soda, Akinobu; Carrasco Apolinario, Magdeline E; Mori, Kenji; Shin, Toshitaka; Miyazato, Mikiya; Mimata, Hiromitsu; Hikida, Takatoshi; Hanada, Toshikatsu; Nakao, Kazuwa; Kangawa, Kenji; Hanada, Reiko.
Afiliación
  • Anan M; Department of Neurophysiology, Faculty of Medicine, Oita University, Oita, Japan.
  • Higa R; Department of Neurophysiology, Faculty of Medicine, Oita University, Oita, Japan.
  • Shikano K; Department of Neurophysiology, Faculty of Medicine, Oita University, Oita, Japan.
  • Shide M; Department of Neurophysiology, Faculty of Medicine, Oita University, Oita, Japan.
  • Soda A; Department of Neurophysiology, Faculty of Medicine, Oita University, Oita, Japan.
  • Carrasco Apolinario ME; Department of Neurophysiology, Faculty of Medicine, Oita University, Oita, Japan.
  • Mori K; Department of Biochemistry, National Cerebral and Cardiovascular Center Research Institute, Osaka, Japan.
  • Shin T; Department of Urology, Faculty of Medicine, Oita University, Oita, Japan.
  • Miyazato M; Department of Biochemistry, National Cerebral and Cardiovascular Center Research Institute, Osaka, Japan.
  • Mimata H; Department of Urology, Faculty of Medicine, Oita University, Oita, Japan.
  • Hikida T; Laboratory for Advanced Brain Functions, Institute for Protein Research, Osaka University, Osaka, Japan.
  • Hanada T; Department of Cell Biology, Faculty of Medicine, Oita University, Oita, Japan.
  • Nakao K; Medical Innovation Center, Kyoto University Graduate School of Medicine, Kyoto, Japan.
  • Kangawa K; Department of Biochemistry, National Cerebral and Cardiovascular Center Research Institute, Osaka, Japan.
  • Hanada R; Department of Neurophysiology, Faculty of Medicine, Oita University, Oita, Japan.
Heliyon ; 6(5): e03947, 2020 May.
Article en En | MEDLINE | ID: mdl-32462086
Neuromedin U (NMU) is a bioactive neuropeptide, highly distributed in the gastrointestinal tract and the central nervous system. NMU has various physiological functions related to feeding behavior, energy metabolism, stress responses, circadian rhythmicity and inflammation. Recently, several reports indicate that the central NMU system plays an important role in the reward systems in the brain. However, the underlying molecular mechanisms are not yet fully defined. In this study, we found that some of cocaine-induced c-Fos immunoreactive cells were co-localized with NMU in the nucleus accumbens (NAc), caudate putamen (CPu), and basolateral amygdala (BLA), which are key brain regions associated with the brain reward system, in wild type mice. Whereas, a treatment with cocaine did not influence the kinetics of NMU or NMU receptors mRNA expression in these brain regions, and NMU-knockout mice did not show any higher preference for cocaine compared with their control mice. These results indicate that cocaine has some effect on NMU expressing neurons related to the brain reward system, and this suggests NMU system may have a role on the brain reward systems activated by cocaine.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Heliyon Año: 2020 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Heliyon Año: 2020 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Reino Unido