Your browser doesn't support javascript.
loading
Serum and placental periostin levels in women with early pregnancy loss.
Eroglu, Semra; Colak, Eser; Erinanc, Ozgur Hilal; Ozdemir, Duygu; Ceran, Mehmet Ufuk; Tasdemir, Umit; Kulaksizoglu, Sevsen; Ozcimen, Emel Ebru.
Afiliación
  • Eroglu S; Department of Gynecology and Obstetrics, Baskent University, Konya, Turkey. Electronic address: drsemraeroglu@gmail.com.
  • Colak E; Department of Gynecology and Obstetrics, Baskent University, Konya, Turkey.
  • Erinanc OH; Department of Pathology, Baskent University, Konya, Turkey.
  • Ozdemir D; Department of Gynecology and Obstetrics, Baskent University, Konya, Turkey.
  • Ceran MU; Department of Gynecology and Obstetrics, Baskent University, Konya, Turkey.
  • Tasdemir U; Department of Gynecology and Obstetrics, Baskent University, Konya, Turkey.
  • Kulaksizoglu S; Department of Biochemistry, Baskent University, Konya, Turkey.
  • Ozcimen EE; Department of Gynecology and Obstetrics, Baskent University, Konya, Turkey.
J Reprod Immunol ; 140: 103138, 2020 08.
Article en En | MEDLINE | ID: mdl-32460058
OBJECTIVES: Periostin is secreted from the placenta in the embryonic period and it is emphasized that it may be involved in endometrial implantation. In this study, we aimed to investigate periostin serum levels and placental tissue expression in first trimester pregnancy losses. STUDY DESIGN: In this prospective case-control study, 30 patients who underwent dilatation and curettage with first trimester spontaneous abortion (<10 weeks of gestation) were included in the study group and 30 patients who had voluntary pregnancy termination (<10 gestational weeks) were included in the control group. Serum samples collected from the study and control groups were analyzed usingenzyme-linkedimmunosorbent assay (ELISA), and trophoblastic and decidual tissues were examined using immunohistochemical staining with streptavidin-biotin-peroxidase techniques. RESULTS: There were no significant differences between the groups in terms of age, gravida status, parity number, gestational week, and number of previous abortions. In the spontaneous abortion group, the serum level of periostin was significantly lower than in the voluntary termination group (6.56 ± 4.16 pg/mLvs. 9.51 ± 4.52 pg/mL, p = 0.03). There was no significant difference between the two groups in terms of periostin expression in decidual and trophoblastic tissue (p = 0.617, p = 0.274, p = 0.497). CONCLUSION: Periostin serum levels were significantly reduced in patients with spontaneous pregnancy loss. Periostin can be used as a predictive marker for the success of endometrial implantation.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Placenta / Trofoblastos / Biomarcadores / Moléculas de Adhesión Celular / Aborto Espontáneo / Suero Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Pregnancy Idioma: En Revista: J Reprod Immunol Año: 2020 Tipo del documento: Article Pais de publicación: Irlanda
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Placenta / Trofoblastos / Biomarcadores / Moléculas de Adhesión Celular / Aborto Espontáneo / Suero Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Pregnancy Idioma: En Revista: J Reprod Immunol Año: 2020 Tipo del documento: Article Pais de publicación: Irlanda