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Latent and Overt Polyautoimmunity in Children and Adolescents With Immune Thrombocytopenia.
Kamioka, Priscila E; Liphaus, Bernadete L; Beatrice, Julia M; Matsumoto, Lucy C; Reis, Joyce M A; Lima, Laila; Carneiro-Sampaio, Magda M S; Carneiro, Jorge D A.
Afiliación
  • Kamioka PE; Pediatric Hematology Unit.
  • Liphaus BL; Laboratory of Medical Investigation, Children's Institute, Faculty of Medicine, University of São Paulo, São Paulo, Brazil.
  • Beatrice JM; Pediatric Hematology Unit.
  • Matsumoto LC; Pediatric Hematology Unit.
  • Reis JMA; Laboratory of Medical Investigation, Children's Institute, Faculty of Medicine, University of São Paulo, São Paulo, Brazil.
  • Lima L; Laboratory of Medical Investigation, Children's Institute, Faculty of Medicine, University of São Paulo, São Paulo, Brazil.
  • Carneiro-Sampaio MMS; Laboratory of Medical Investigation, Children's Institute, Faculty of Medicine, University of São Paulo, São Paulo, Brazil.
  • Carneiro JDA; Pediatric Hematology Unit.
J Pediatr Hematol Oncol ; 42(7): e606-e609, 2020 10.
Article en En | MEDLINE | ID: mdl-32459722
Autoantibodies are biomarkers for autoimmune disease diagnosis, monitoring, and prediction. Therefore, this study established the frequency of latent and overt polyautoimmunity in children and adolescents with >6 months of diagnosis of immune thrombocytopenia (ITP). Forty-seven patients with chronic or persistent disease had non-organ-specific and organ-specific autoantibodies assessed. Frequency of latent polyautoimmunity was 36.2%, and, of overt polyautoimmunity, it was 4.3%. Of ITP patients with latent polyautoimmunity, 52.9% were positive for antinuclear antibody (ANA), 47.1% for autoantibodies other than ANA, and 64.7% for multiple autoantibodies. In addition, patients with latent polyautoimmunity and those positive for ANA were significantly older at disease onset. Both ITP patients positive and negative for autoantibodies reported family members with autoimmune diseases. The autoantibodies observed were as follows: ANA, anti-dsDNA, anti-SSA/Ro, IgM aCL, anti-GAD, anti-IA2, anti-IAA, anti-TG, anti-TPO, anti-LKM1, and SMA. Of ITP patients with overt polyautoimmunity, 1 was diagnosed with type 1 diabetes mellitus and the other with thyroiditis. In conclusion, children and adolescents with ITP present high frequency of latent and overt polyautoimmunity even for autoantibodies other than ANA. Therefore, ANA and other non-organ-specific and organ-specific autoantibodies should be considered for assessment during ITP patients' follow-up.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Autoanticuerpos / Púrpura Trombocitopénica Idiopática Tipo de estudio: Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Adolescent / Child / Female / Humans / Male Idioma: En Revista: J Pediatr Hematol Oncol Asunto de la revista: HEMATOLOGIA / NEOPLASIAS / PEDIATRIA Año: 2020 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Autoanticuerpos / Púrpura Trombocitopénica Idiopática Tipo de estudio: Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Adolescent / Child / Female / Humans / Male Idioma: En Revista: J Pediatr Hematol Oncol Asunto de la revista: HEMATOLOGIA / NEOPLASIAS / PEDIATRIA Año: 2020 Tipo del documento: Article Pais de publicación: Estados Unidos