Genome Maintenance by DNA Helicase B.

Hazeslip, Lindsey; Zafar, Maroof Khan; Chauhan, Muhammad Zain; Byrd, Alicia K

Hazeslip, Lindsey; Zafar, Maroof Khan; Chauhan, Muhammad Zain; Byrd, Alicia K.

Afiliación

Hazeslip L; Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
Zafar MK; Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
Chauhan MZ; Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
Byrd AK; Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.

Genes (Basel) ; 11(5)2020 05 21.

Article en En | MEDLINE | ID: mdl-32455610

RESUMEN

DNA Helicase B (HELB) is a conserved helicase in higher eukaryotes with roles in the initiation of DNA replication and in the DNA damage and replication stress responses. HELB is a predominately nuclear protein in G1 phase where it is involved in initiation of DNA replication through interactions with DNA topoisomerase 2-binding protein 1 (TOPBP1), cell division control protein 45 (CDC45), and DNA polymerase α-primase. HELB also inhibits homologous recombination by reducing long-range end resection. After phosphorylation by cyclin-dependent kinase 2 (CDK2) at the G1 to S transition, HELB is predominately localized to the cytosol. However, this cytosolic localization in S phase is not exclusive. HELB has been reported to localize to chromatin in response to replication stress and to localize to the common fragile sites 16D (FRA16D) and 3B (FRA3B) and the rare fragile site XA (FRAXA) in S phase. In addition, HELB is phosphorylated in response to ionizing radiation and has been shown to localize to chromatin in response to various types of DNA damage, suggesting it has a role in the DNA damage response.

Asunto(s)

Proteínas Portadoras/genética; ADN Helicasas/genética; Replicación del ADN/genética; Proteínas de Unión al ADN/genética; Recombinación Homóloga/genética; Proteínas Nucleares/genética; Proteínas de Ciclo Celular/genética; Cromatina/genética; Sitios Frágiles del Cromosoma/genética; Quinasa 2 Dependiente de la Ciclina/genética; Roturas del ADN de Doble Cadena; Daño del ADN/genética; ADN Polimerasa I/genética; ADN Primasa/genética; Eucariontes/genética; Puntos de Control de la Fase G1 del Ciclo Celular/genética; Genoma Humano; Humanos; Fosforilación/genética; Fase S/genética

Palabras clave

DNA damage; DNA helicase; DNA repair; DNA replication; genomic stability

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas Nucleares / Proteínas Portadoras / ADN Helicasas / Proteínas de Unión al ADN / Replicación del ADN / Recombinación Homóloga Límite: Humans Idioma: En Revista: Genes (Basel) Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza

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