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Behavioral and Neural Signatures of Working Memory in Childhood.
Rosenberg, Monica D; Martinez, Steven A; Rapuano, Kristina M; Conley, May I; Cohen, Alexandra O; Cornejo, M Daniela; Hagler, Donald J; Meredith, Wesley J; Anderson, Kevin M; Wager, Tor D; Feczko, Eric; Earl, Eric; Fair, Damien A; Barch, Deanna M; Watts, Richard; Casey, B J.
Afiliación
  • Rosenberg MD; Department of Psychology, University of Chicago, Chicago, IL 60637 mdrosenberg@uchicago.edu bj.casey@yale.edu.
  • Martinez SA; Department of Psychology, Yale University, New Haven, CT 06511.
  • Rapuano KM; Department of Psychology, Yale University, New Haven, CT 06511.
  • Conley MI; Department of Psychology, Yale University, New Haven, CT 06511.
  • Cohen AO; Department of Psychology, Yale University, New Haven, CT 06511.
  • Cornejo MD; Department of Psychology and Neural Science, New York University, New York, NY 10003.
  • Hagler DJ; Department of Radiology, University of California, San Diego, San Diego, CA 92122.
  • Meredith WJ; Institute of Physics, Pontificia Universidad Católica de Chile, Santiago 8331150, Chile.
  • Anderson KM; Department of Radiology, University of California, San Diego, San Diego, CA 92122.
  • Wager TD; Department of Psychology, University of Chicago, Chicago, IL 60637.
  • Feczko E; Department of Psychology, Yale University, New Haven, CT 06511.
  • Earl E; Department of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO 80302.
  • Fair DA; Department of Psychological and Brain Sciences, Dartmouth College, Hanover, NH 03755.
  • Barch DM; Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, OR 97239.
  • Watts R; Department of Medical Informatics and Clinical Epidemiology, Oregon Health & Science University, Portland, OR 97239.
  • Casey BJ; Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, OR 97239.
J Neurosci ; 40(26): 5090-5104, 2020 06 24.
Article en En | MEDLINE | ID: mdl-32451322
Working memory function changes across development and varies across individuals. The patterns of behavior and brain function that track individual differences in working memory during human development, however, are not well understood. Here, we establish associations between working memory, other cognitive abilities, and functional MRI (fMRI) activation in data from over 11,500 9- to 10-year-old children (both sexes) enrolled in the Adolescent Brain Cognitive Development (ABCD) Study, an ongoing longitudinal study in the United States. Behavioral analyses reveal robust relationships between working memory, short-term memory, language skills, and fluid intelligence. Analyses relating out-of-scanner working memory performance to memory-related fMRI activation in an emotional n-back task demonstrate that frontoparietal activity during a working memory challenge indexes working memory performance. This relationship is domain specific, such that fMRI activation related to emotion processing during the emotional n-back task, inhibitory control during a stop-signal task (SST), and reward processing during a monetary incentive delay (MID) task does not track memory abilities. Together, these results inform our understanding of individual differences in working memory in childhood and lay the groundwork for characterizing the ways in which they change across adolescence.SIGNIFICANCE STATEMENT Working memory is a foundational cognitive ability that changes over time and varies across individuals. Here, we analyze data from over 11,500 9- to 10-year-olds to establish relationships between working memory, other cognitive abilities, and frontoparietal brain activity during a working memory challenge, but not during other cognitive challenges. Our results lay the groundwork for assessing longitudinal changes in working memory and predicting later academic and other real-world outcomes.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Encéfalo / Desarrollo Infantil / Memoria a Corto Plazo Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Child / Female / Humans / Male Idioma: En Revista: J Neurosci Año: 2020 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Encéfalo / Desarrollo Infantil / Memoria a Corto Plazo Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Child / Female / Humans / Male Idioma: En Revista: J Neurosci Año: 2020 Tipo del documento: Article Pais de publicación: Estados Unidos