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Potential Markers of Dietary Glycemic Exposures for Sustained Dietary Interventions in Populations without Diabetes.
Feskens, Edith; Brennan, Lorraine; Dussort, Pierre; Flourakis, Matthieu; Lindner, Lena M E; Mela, David; Rabbani, Naila; Rathmann, Wolfgang; Respondek, Frédérique; Stehouwer, Coen; Theis, Stephan; Thornalley, Paul; Vinoy, Sophie.
Afiliación
  • Feskens E; Department of Agrotechnology and Food Sciences, Wageningen University, Wageningen, The Netherlands.
  • Brennan L; Institute of Food and Health, School of Agriculture and Food Science, University College Dublin, Dublin, Republic of Ireland.
  • Dussort P; International Life Sciences Institute-ILSI Europe a.i.s.b.l., Brussels, Belgium.
  • Flourakis M; International Life Sciences Institute-ILSI Europe a.i.s.b.l., Brussels, Belgium.
  • Lindner LME; Institute for Biometrics and Epidemiology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany.
  • Mela D; German Center for Diabetes Research , Munich, Germany.
  • Rabbani N; Valkenswaard, The Netherlands.
  • Rathmann W; Department of Basic Medical Sciences, College of Medicine, Qatar University Health, Qatar University, Doha, Qatar.
  • Respondek F; Clinical Sciences Research Laboratories, University of Warwick, Coventry, United Kingdom.
  • Stehouwer C; Institute for Biometrics and Epidemiology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany.
  • Theis S; German Center for Diabetes Research , Munich, Germany.
  • Thornalley P; Tereos, Marckolsheim, France, Belgium.
  • Vinoy S; Department of Internal Medicine, Maastricht University Medical Center, Maastricht, The Netherlands.
Adv Nutr ; 11(5): 1221-1236, 2020 09 01.
Article en En | MEDLINE | ID: mdl-32449931
There is considerable interest in dietary and other approaches to maintaining blood glucose concentrations within the normal range and minimizing exposure to postprandial hyperglycemic excursions. The accepted marker to evaluate the sustained maintenance of normal blood glucose concentrations is glycated hemoglobin A1c (HbA1c). However, although this is used in clinical practice to monitor glycemic control in patients with diabetes, it has a number of drawbacks as a marker of efficacy of dietary interventions that might beneficially affect glycemic control in people without diabetes. Other markers that reflect shorter-term glycemic exposures have been studied and proposed, but consensus on the use and relevance of these markers is lacking. We have carried out a systematic search for studies that have tested the responsiveness of 6 possible alternatives to HbA1c as markers of sustained variation in glycemic exposures and thus their potential applicability for use in dietary intervention trials in subjects without diabetes: 1,5-anhydroglucitol (1,5-AG), dicarbonyl stress, fructosamine, glycated albumin (GA), advanced glycated end products (AGEs), and metabolomic profiles. The results suggest that GA may be the most promising for this purpose, but values may be confounded by effects of fat mass. 1,5-AG and fructosamine are probably not sensitive enough to the range of variation in glycemic exposures observed in healthy individuals. Use of measures based on dicarbonyls, AGEs, or metabolomic profiles would require further research into possible specific molecular species of interest. At present, none of the markers considered here is sufficiently validated and sensitive for routine use in substantiating the effects of sustained variation in dietary glycemic exposures in people without diabetes.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Glucemia / Diabetes Mellitus Tipo de estudio: Systematic_reviews Límite: Humans Idioma: En Revista: Adv Nutr Año: 2020 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Glucemia / Diabetes Mellitus Tipo de estudio: Systematic_reviews Límite: Humans Idioma: En Revista: Adv Nutr Año: 2020 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Estados Unidos