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Long-term resveratrol treatment improves the capillarization in the skeletal muscles of ageing C57BL/6J mice.
Toniolo, Luana; Formoso, Luca; Torelli, Lucio; Crea, Emanuela; Bergamo, Alberta; Sava, Gianni; Giacomello, Emiliana.
Afiliación
  • Toniolo L; Department of Biomedical Sciences, University of Padova, Padova, Italy.
  • Formoso L; Department of Molecular and Developmental Medicine, University of Siena, Siena, Italy.
  • Torelli L; Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy.
  • Crea E; Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy.
  • Bergamo A; Callerio Foundation Onlus, Trieste, Italy.
  • Sava G; Department of Life Sciences, University of Trieste, Trieste, Italy.
  • Giacomello E; Callerio Foundation Onlus, Trieste, Italy.
Int J Food Sci Nutr ; 72(1): 37-44, 2021 Feb.
Article en En | MEDLINE | ID: mdl-32449407
We recently showed that the treatment with Resveratrol (RES) contrasts the effects of ageing on the skeletal muscle (SKM), reduces the appearance of tubular aggregates (TAs), and improves the fatigue resistance. Since fatigue resistance depends on the SKM capillary network, and RES has been described to improve vascularisation, we analysed the SKM capillarization in naturally ageing C57BL/6J male mice, fed with 0.04% RES in the diet for 6 months, which showed a better fatigue resistance in a previous work. Our data show an inverse correlation between the number of capillaries per fibre (CAF) and TAs in both control and treated type IIB fibres, and an increase of CAF in ageing SKM upon RES-treatment. The present work suggests that capillarization is one of the determinants of the development of TAs and fatigue resistance, and that RES can be considered a good candidate to counteract capillary rarefaction in the SKM tissue.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Envejecimiento / Capilares / Músculo Esquelético / Resveratrol Límite: Animals Idioma: En Revista: Int J Food Sci Nutr Asunto de la revista: CIENCIAS DA NUTRICAO Año: 2021 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Envejecimiento / Capilares / Músculo Esquelético / Resveratrol Límite: Animals Idioma: En Revista: Int J Food Sci Nutr Asunto de la revista: CIENCIAS DA NUTRICAO Año: 2021 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Reino Unido