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Discrete populations of isotype-switched memory B lymphocytes are maintained in murine spleen and bone marrow.
Riedel, René; Addo, Richard; Ferreira-Gomes, Marta; Heinz, Gitta Anne; Heinrich, Frederik; Kummer, Jannis; Greiff, Victor; Schulz, Daniel; Klaeden, Cora; Cornelis, Rebecca; Menzel, Ulrike; Kröger, Stefan; Stervbo, Ulrik; Köhler, Ralf; Haftmann, Claudia; Kühnel, Silvia; Lehmann, Katrin; Maschmeyer, Patrick; McGrath, Mairi; Naundorf, Sandra; Hahne, Stefanie; Sercan-Alp, Özen; Siracusa, Francesco; Stefanowski, Jonathan; Weber, Melanie; Westendorf, Kerstin; Zimmermann, Jakob; Hauser, Anja E; Reddy, Sai T; Durek, Pawel; Chang, Hyun-Dong; Mashreghi, Mir-Farzin; Radbruch, Andreas.
Afiliación
  • Riedel R; Deutsches Rheuma-Forschungszentrum (DRFZ), an Institute of the Leibniz Association, 10117, Berlin, Germany.
  • Addo R; Evolutionary Genomics Group, Max Planck Institute for Evolutionary Biology, 24306, Plön, Germany.
  • Ferreira-Gomes M; Deutsches Rheuma-Forschungszentrum (DRFZ), an Institute of the Leibniz Association, 10117, Berlin, Germany.
  • Heinz GA; Deutsches Rheuma-Forschungszentrum (DRFZ), an Institute of the Leibniz Association, 10117, Berlin, Germany.
  • Heinrich F; Deutsches Rheuma-Forschungszentrum (DRFZ), an Institute of the Leibniz Association, 10117, Berlin, Germany.
  • Kummer J; Deutsches Rheuma-Forschungszentrum (DRFZ), an Institute of the Leibniz Association, 10117, Berlin, Germany.
  • Greiff V; Deutsches Rheuma-Forschungszentrum (DRFZ), an Institute of the Leibniz Association, 10117, Berlin, Germany.
  • Schulz D; Department of Biosystems Science and Engineering, Eidgenössische Technische Hochschule (ETH Zürich), CH-4058, Basel, Switzerland.
  • Klaeden C; Department of Immunology, Institute of Clinical Medicine, University of Oslo, 0424, Oslo, Norway.
  • Cornelis R; Deutsches Rheuma-Forschungszentrum (DRFZ), an Institute of the Leibniz Association, 10117, Berlin, Germany.
  • Menzel U; Deutsches Rheuma-Forschungszentrum (DRFZ), an Institute of the Leibniz Association, 10117, Berlin, Germany.
  • Kröger S; Deutsches Rheuma-Forschungszentrum (DRFZ), an Institute of the Leibniz Association, 10117, Berlin, Germany.
  • Stervbo U; Department of Biosystems Science and Engineering, Eidgenössische Technische Hochschule (ETH Zürich), CH-4058, Basel, Switzerland.
  • Köhler R; Knowledge Management in Bioinformatics, Humboldt-Universität zu Berlin, 12489, Berlin, Germany.
  • Haftmann C; Department of Infectious Disease Epidemiology, Robert Koch Institute, 13353, Berlin, Germany.
  • Kühnel S; Deutsches Rheuma-Forschungszentrum (DRFZ), an Institute of the Leibniz Association, 10117, Berlin, Germany.
  • Lehmann K; Charité-Universitätsmedizin Berlin, 10117, Berlin, Germany.
  • Maschmeyer P; Deutsches Rheuma-Forschungszentrum (DRFZ), an Institute of the Leibniz Association, 10117, Berlin, Germany.
  • McGrath M; Deutsches Rheuma-Forschungszentrum (DRFZ), an Institute of the Leibniz Association, 10117, Berlin, Germany.
  • Naundorf S; Institute of Experimental Immunology, Universitätsspital Zürich, 8057, Zürich, Switzerland.
  • Hahne S; Deutsches Rheuma-Forschungszentrum (DRFZ), an Institute of the Leibniz Association, 10117, Berlin, Germany.
  • Sercan-Alp Ö; Deutsches Rheuma-Forschungszentrum (DRFZ), an Institute of the Leibniz Association, 10117, Berlin, Germany.
  • Siracusa F; Deutsches Rheuma-Forschungszentrum (DRFZ), an Institute of the Leibniz Association, 10117, Berlin, Germany.
  • Stefanowski J; Deutsches Rheuma-Forschungszentrum (DRFZ), an Institute of the Leibniz Association, 10117, Berlin, Germany.
  • Weber M; Deutsches Rheuma-Forschungszentrum (DRFZ), an Institute of the Leibniz Association, 10117, Berlin, Germany.
  • Westendorf K; Deutsches Rheuma-Forschungszentrum (DRFZ), an Institute of the Leibniz Association, 10117, Berlin, Germany.
  • Zimmermann J; Deutsches Rheuma-Forschungszentrum (DRFZ), an Institute of the Leibniz Association, 10117, Berlin, Germany.
  • Hauser AE; R&D, TA Immunology & Inflammation Research, Sanofi-Aventis Deutschland GmbH, Industriepark Hoechst, 65926, Frankfurt am Main, Germany.
  • Reddy ST; Deutsches Rheuma-Forschungszentrum (DRFZ), an Institute of the Leibniz Association, 10117, Berlin, Germany.
  • Durek P; Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, 20246, Hamburg, Germany.
  • Chang HD; Deutsches Rheuma-Forschungszentrum (DRFZ), an Institute of the Leibniz Association, 10117, Berlin, Germany.
  • Mashreghi MF; Charité-Universitätsmedizin Berlin, 10117, Berlin, Germany.
  • Radbruch A; Deutsches Rheuma-Forschungszentrum (DRFZ), an Institute of the Leibniz Association, 10117, Berlin, Germany.
Nat Commun ; 11(1): 2570, 2020 05 22.
Article en En | MEDLINE | ID: mdl-32444631
At present, it is not clear how memory B lymphocytes are maintained over time, and whether only as circulating cells or also residing in particular tissues. Here we describe distinct populations of isotype-switched memory B lymphocytes (Bsm) of murine spleen and bone marrow, identified according to individual transcriptional signature and B cell receptor repertoire. A population of marginal zone-like cells is located exclusively in the spleen, while a population of quiescent Bsm is found only in the bone marrow. Three further resident populations, present in spleen and bone marrow, represent transitional and follicular B cells and B1 cells, respectively. A population representing 10-20% of spleen and bone marrow memory B cells is the only one qualifying as circulating. In the bone marrow, all cells individually dock onto VCAM1+ stromal cells and, reminiscent of resident memory T and plasma cells, are void of activation, proliferation and mobility.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Bazo / Células de la Médula Ósea / Linfocitos B / Cambio de Clase de Inmunoglobulina / Memoria Inmunológica Límite: Animals Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2020 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Bazo / Células de la Médula Ósea / Linfocitos B / Cambio de Clase de Inmunoglobulina / Memoria Inmunológica Límite: Animals Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2020 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Reino Unido