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Pilocarpine-induced status epilepticus reduces chemosensory control of breathing.
Maia, Octávio A C; Malheiros-Lima, Milene R; Oliveira, Maria A; Castro, Claudio L; Moriya, Henrique T; Tavares-de-Lima, Wothan; Takakura, Ana C; Moreira, Thiago S.
Afiliación
  • Maia OAC; Department of Physiology and Biophysics, Institute of Biomedical Science, University of Sao Paulo, 1524 Prof Lineu Prestes Av 05508-000, Sao Paulo, SP, Brazil.
  • Malheiros-Lima MR; Department of Physiology and Biophysics, Institute of Biomedical Science, University of Sao Paulo, 1524 Prof Lineu Prestes Av 05508-000, Sao Paulo, SP, Brazil.
  • Oliveira MA; Department of Pharmacology, Institute of Biomedical Science, University of Sao Paulo, Sao Paulo, SP, Brazil.
  • Castro CL; Department of Physiology and Biophysics, Institute of Biomedical Science, University of Sao Paulo, 1524 Prof Lineu Prestes Av 05508-000, Sao Paulo, SP, Brazil.
  • Moriya HT; Department of Engineering of Control and Telecommunication, University of Sao Paulo, Sao Paulo, SP, Brazil.
  • Tavares-de-Lima W; Department of Pharmacology, Institute of Biomedical Science, University of Sao Paulo, Sao Paulo, SP, Brazil.
  • Takakura AC; Department of Pharmacology, Institute of Biomedical Science, University of Sao Paulo, Sao Paulo, SP, Brazil.
  • Moreira TS; Department of Physiology and Biophysics, Institute of Biomedical Science, University of Sao Paulo, 1524 Prof Lineu Prestes Av 05508-000, Sao Paulo, SP, Brazil. Electronic address: tmoreira@icb.usp.br.
Brain Res Bull ; 161: 98-105, 2020 08.
Article en En | MEDLINE | ID: mdl-32433938
One of the possible causes of death in epilepsy is breathing disorders, especially apneas, which lead to an increase in CO2 levels (hypercapnia) and/or a decrease in O2 levels in arterial blood (hypoxemia). The respiratory neurons located in the ventral brainstem respiratory column are the main groups responsible for controlling breathing. Recent data from our group demonstrated respiratory changes in two experimental models of epilepsy, i.e. audiogenic epilepsy, and amygdala rapid kindling. Here, we aimed to evaluate respiratory changes in the classic model of temporal lobe epilepsy induced by intra-hippocampal injection of pilocarpine. Adult Wistar rats with stainless-steel cannulas implanted in the hippocampus region were used. The animals were submitted to pilocarpine injection (2.4 mg/µL, N = 12-15) or saline (N = 9) into the hippocampus. The respiratory parameters analyzed by whole-body plethysmography were respiratory rate (fR), tidal volume (VT) and ventilation (VE). Respiratory mechanics such as Newtonian airway resistance (Rn), viscance of the pulmonary parenchyma (G) and the elastance of the pulmonary parenchyma (H) were also investigated. No changes in baseline breathing were detected 15 or 30 days after pilocarpine-induced status epilepticus (SE). However, 30 days after pilocarpine-induced SE, a significant reduction in VE was observed during hypercapnic (7% CO2) stimulation, without affecting the hypoxia (8% O2) ventilatory response. We also did not observe changes in respiratory mechanics. The present results suggest that the impairment of the hypercapnia ventilatory response in pilocarpine-induced SE could be related to a presumable degeneration of brainstem respiratory neurons but not to peripheral mechanisms.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pilocarpina / Respiración / Estado Epiléptico / Células Quimiorreceptoras / Volumen de Ventilación Pulmonar Límite: Animals Idioma: En Revista: Brain Res Bull Año: 2020 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pilocarpina / Respiración / Estado Epiléptico / Células Quimiorreceptoras / Volumen de Ventilación Pulmonar Límite: Animals Idioma: En Revista: Brain Res Bull Año: 2020 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Estados Unidos