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Dissociation of Neural Mechanisms for Intersensory Timing Deficits in Parkinson's Disease.
Harrington, Deborah L; Castillo, Gabriel N; Reed, Jason D; Song, David D; Litvan, Irene; Lee, Roland R.
Afiliación
  • Harrington DL; Research Service, VA San Diego Healthcare System, San Diego, CA, USA.
  • Castillo GN; Department of Radiology, University of California San Diego, La Jolla, CA, USA.
  • Reed JD; Research Service, VA San Diego Healthcare System, San Diego, CA, USA.
  • Song DD; Department of Radiology, University of California San Diego, La Jolla, CA, USA.
  • Litvan I; Research Service, VA San Diego Healthcare System, San Diego, CA, USA.
  • Lee RR; Department of Radiology, University of California San Diego, La Jolla, CA, USA.
Timing Time Percept ; 2(2): 145-168, 2014 May 19.
Article en En | MEDLINE | ID: mdl-32432026
This study investigated the ability of individuals with Parkinson's disease (PD) to synthesize temporal information across the senses, namely audition and vision. Auditory signals (A) are perceived as lasting longer than visual signals (V) when they are compared together, since attentsion is captured and sustained more easily than for visual information. We used the audiovisual illusion to probe for disturbances in brain networks that govern the resolution of time in two intersensory conditions that putatively differ in their attention demands. PD patients and controls judged the relative duration of successively presented pairs of unimodal (AA, VV) and crossmodal (VA, AV) signals whilst undergoing fMRI. There were four main findings. First, underestimation of time was exaggerated in PD when timing depended on controlled attention (AV), whereas subtle deficits were found when audition dominated and attention was more easily sustained (VA). Second, group differences in regional activation were observed only for the AV-unimodal comparison, where the PD group failed to modulate basal ganglia, anterior insula, and inferior cerebellum activity in accord with the timing condition. Third, the intersensory timing conditions were dissociated by patterns of abnormal functional connectivity. When intersensory timing emphasized controlled attention, patients showed weakened connectivity of the cortico-thalamus-basal ganglia (CTBG) circuit and the anterior insula with widespread cortical regions, yet enhanced cerebellar connectivity. When audition dominated intersensory timing, patients showed enhanced connectivity of CTBG elements, the anterior insula, and the cerebellum with the caudate tail and frontal cortex. Fourth, abnormal connectivity measures showed excellent sensitivity and specificity in accurately classifying subjects. The results demonstrate that intersensory timing deficits in PD were well characterized by context-dependent patterns of functional connectivity within a presumed core timing system (CTBG) and a ventral attention hub (anterior insula), and enhanced cerebellar connectivity irrespective of the hypothesized attention demands of timing.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Timing Time Percept Año: 2014 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Países Bajos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Timing Time Percept Año: 2014 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Países Bajos