Developmental neurotoxicity after penconazole exposure at embryo pre- and post-implantation in mice.
J Histotechnol
; 43(3): 135-146, 2020 09.
Article
en En
| MEDLINE
| ID: mdl-32427060
The present study was conducted to evaluate the effect of penconazole fungicide at a low dose (2.5 mg/kg b.w.) during embryogenesis in either the pre- or post-implantation of embryos. Females were determined pregnant according to the presence of vaginal plug and then grouped into control and penconazole-exposures at high doses (30, 20, 10, and 5 mg/kg b.w.). These high doses provoked foetoresorptionin the first experiment. Thus, a low dose (2.5 mg/kg b. w.) was used in either the pre- or post-implantation of embryos to clarify the embryotoxicity without mortality on the developing brain and eye. Results indicate a developmental delay of the cerebral hemisphere, hippocampus, cerebellum (lobulation) and induced retinopathy during eye development in post-implantation of penconazole treated group. Also, the effect of penconazole at low dose provoked a decrease in the expression of α-synuclein in the hippocampus, cerebellum, and ganglion cell layer of the developing brain and eye. In conclusion, exposure to PEN fungicide during pregnancy at a dose (2.5 mg/kg) induces alterations in the developing brain and eye tissues.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Implantación del Embrión
/
Triazoles
/
Desarrollo Embrionario
/
Fungicidas Industriales
Límite:
Animals
/
Pregnancy
Idioma:
En
Revista:
J Histotechnol
Año:
2020
Tipo del documento:
Article
País de afiliación:
Egipto
Pais de publicación:
Reino Unido