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Abolishing spontaneous epileptiform activity in human brain tissue through AMPA receptor inhibition.
Wright, Sukhvir K; Wilson, Max A; Walsh, Richard; Lo, William B; Mundil, Nilesh; Agrawal, Shakti; Philip, Sunny; Seri, Stefano; Greenhill, Stuart D; Woodhall, Gavin L.
Afiliación
  • Wright SK; Aston Neuroscience Institute, School of Life and Health Sciences, Aston University, Birmingham, UK.
  • Wilson MA; Department of Paediatric Neurology, The Birmingham Women's and Children's Hospital NHS Foundation Trust, Birmingham, UK.
  • Walsh R; Aston Neuroscience Institute, School of Life and Health Sciences, Aston University, Birmingham, UK.
  • Lo WB; Department of Paediatric Neurosurgery, The Birmingham Women's and Children's Hospital NHS Foundation Trust, Birmingham, UK.
  • Mundil N; Department of Paediatric Neurosurgery, The Birmingham Women's and Children's Hospital NHS Foundation Trust, Birmingham, UK.
  • Agrawal S; Department of Paediatric Neurosurgery, The Birmingham Women's and Children's Hospital NHS Foundation Trust, Birmingham, UK.
  • Philip S; Department of Paediatric Neurology, The Birmingham Women's and Children's Hospital NHS Foundation Trust, Birmingham, UK.
  • Seri S; Department of Paediatric Neurology, The Birmingham Women's and Children's Hospital NHS Foundation Trust, Birmingham, UK.
  • Greenhill SD; Aston Neuroscience Institute, School of Life and Health Sciences, Aston University, Birmingham, UK.
  • Woodhall GL; Department of Clinical Neurophysiology, The Birmingham Women's and Children's Hospital, NHS Foundation Trust, Birmingham, UK.
Ann Clin Transl Neurol ; 7(6): 883-890, 2020 06.
Article en En | MEDLINE | ID: mdl-32426918
OBJECTIVE: The amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) is increasingly recognized as a therapeutic target in drug-refractory pediatric epilepsy. Perampanel (PER) is a non-competitive AMPAR antagonist, and pre-clinical studies have shown the AMPAR-mediated anticonvulsant effects of decanoic acid (DEC), a major medium-chain fatty acid provided in the medium-chain triglyceride ketogenic diet. METHODS: Using brain tissue resected from children with intractable epilepsy, we recorded the effects of PER and DEC in vitro. RESULTS: We found resected pediatric epilepsy tissue exhibits spontaneous epileptic activity in vitro, and showed that DEC and PER inhibit this epileptiform activity in local field potential recordings as well as excitatory synaptic transmission. INTERPRETATION: This study confirms AMPAR antagonists inhibit epileptiform discharges in brain tissue resected in a wide range of pediatric epilepsies.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Piridonas / Receptores AMPA / Ácidos Decanoicos / Epilepsia / Potenciales Sinápticos / Anticonvulsivantes Límite: Adolescent / Child / Child, preschool / Female / Humans / Male Idioma: En Revista: Ann Clin Transl Neurol Año: 2020 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Piridonas / Receptores AMPA / Ácidos Decanoicos / Epilepsia / Potenciales Sinápticos / Anticonvulsivantes Límite: Adolescent / Child / Child, preschool / Female / Humans / Male Idioma: En Revista: Ann Clin Transl Neurol Año: 2020 Tipo del documento: Article Pais de publicación: Estados Unidos