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Evidence-based umbrella review of 162 peripheral biomarkers for major mental disorders.
Carvalho, André F; Solmi, Marco; Sanches, Marcos; Machado, Myrela O; Stubbs, Brendon; Ajnakina, Olesya; Sherman, Chelsea; Sun, Yue Ran; Liu, Celina S; Brunoni, Andre R; Pigato, Giorgio; Fernandes, Brisa S; Bortolato, Beatrice; Husain, Muhammad I; Dragioti, Elena; Firth, Joseph; Cosco, Theodore D; Maes, Michael; Berk, Michael; Lanctôt, Krista L; Vieta, Eduard; Pizzagalli, Diego A; Smith, Lee; Fusar-Poli, Paolo; Kurdyak, Paul A; Fornaro, Michele; Rehm, Jürgen; Herrmann, Nathan.
Afiliación
  • Carvalho AF; Department of Psychiatry, University of Toronto, Toronto, ON, Canada. andrefc7@hotmail.com.
  • Solmi M; Centre for Addiction & Mental Health (CAMH), Toronto, ON, Canada. andrefc7@hotmail.com.
  • Sanches M; Neuroscience Department, University of Padova, Padova, Italy.
  • Machado MO; Neuroscience Center, University of Padova, Padova, Italy.
  • Stubbs B; Early Psychosis: Interventions and Clinical-detection (EPIC) lab, Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
  • Ajnakina O; Centre for Addiction & Mental Health (CAMH), Toronto, ON, Canada.
  • Sherman C; Krembil Centre for NeuroInformatics, Toronto, ON, Canada.
  • Sun YR; Division of Dermatology, Women's College Hospital, Toronto, ON, Canada.
  • Liu CS; Physiotherapy Department, South London and Maudsley NHS Foundation Trust, London, UK.
  • Brunoni AR; Health Service and Population Research Department, Institute of Psychiatry, Psychology and Neuroscience, King's College London, De Crespigny Park, London, UK.
  • Pigato G; Department of Biostatistics & Health Informatics, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
  • Fernandes BS; Neuropsychopharmacology Research Group, Hurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, ON, Canada.
  • Bortolato B; Neuropsychopharmacology Research Group, Hurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, ON, Canada.
  • Husain MI; Neuropsychopharmacology Research Group, Hurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, ON, Canada.
  • Dragioti E; Service of Interdisciplinary Neuromodulation, Laboratory of Neurosciences (LIM-27) and National Institute of Biomarkers in Psychiatry (INBioN), Department and Institute of Psychiatry, University of São Paulo, São Paulo, SP, Brazil.
  • Firth J; Department of Internal Medicine, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
  • Cosco TD; Neuroscience Department, University of Padova, Padova, Italy.
  • Maes M; Neuroscience Center, University of Padova, Padova, Italy.
  • Berk M; Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center, Houston, TX, USA.
  • Lanctôt KL; Department of Mental Health ULSS 8 "Berica", Vicenza, Italy.
  • Vieta E; Department of Psychiatry, University of Toronto, Toronto, ON, Canada.
  • Pizzagalli DA; Centre for Addiction & Mental Health (CAMH), Toronto, ON, Canada.
  • Smith L; Pain and Rehabilitation Centre, and Department of Medical and Health Sciences, Linköping University, SE-581 85, Linköping, Sweden.
  • Fusar-Poli P; NICM Health Research Institute, Western Sydney University, Westmead, Australia.
  • Kurdyak PA; Division of Psychology and Mental Health, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
  • Fornaro M; Gerontology Research Center, Simon Fraser University, Vancouver, Canada.
  • Rehm J; Oxford Institute of Population Ageing, University of Oxford, Oxford, UK.
  • Herrmann N; Department of Psychiatry, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Transl Psychiatry ; 10(1): 152, 2020 05 18.
Article en En | MEDLINE | ID: mdl-32424116
The literature on non-genetic peripheral biomarkers for major mental disorders is broad, with conflicting results. An umbrella review of meta-analyses of non-genetic peripheral biomarkers for Alzheimer's disease, autism spectrum disorder, bipolar disorder (BD), major depressive disorder, and schizophrenia, including first-episode psychosis. We included meta-analyses that compared alterations in peripheral biomarkers between participants with mental disorders to controls (i.e., between-group meta-analyses) and that assessed biomarkers after treatment (i.e., within-group meta-analyses). Evidence for association was hierarchically graded using a priori defined criteria against several biases. The Assessment of Multiple Systematic Reviews (AMSTAR) instrument was used to investigate study quality. 1161 references were screened. 110 met inclusion criteria, relating to 359 meta-analytic estimates and 733,316 measurements, on 162 different biomarkers. Only two estimates met a priori defined criteria for convincing evidence (elevated awakening cortisol levels in euthymic BD participants relative to controls and decreased pyridoxal levels in participants with schizophrenia relative to controls). Of 42 estimates which met criteria for highly suggestive evidence only five biomarker aberrations occurred in more than one disorder. Only 15 meta-analyses had a power >0.8 to detect a small effect size, and most (81.9%) meta-analyses had high heterogeneity. Although some associations met criteria for either convincing or highly suggestive evidence, overall the vast literature of peripheral biomarkers for major mental disorders is affected by bias and is underpowered. No convincing evidence supported the existence of a trans-diagnostic biomarker. Adequately powered and methodologically sound future large collaborative studies are warranted.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Esquizofrenia / Trastorno Bipolar / Trastorno Depresivo Mayor / Trastorno del Espectro Autista / Trastornos Mentales Tipo de estudio: Systematic_reviews Límite: Humans Idioma: En Revista: Transl Psychiatry Año: 2020 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Esquizofrenia / Trastorno Bipolar / Trastorno Depresivo Mayor / Trastorno del Espectro Autista / Trastornos Mentales Tipo de estudio: Systematic_reviews Límite: Humans Idioma: En Revista: Transl Psychiatry Año: 2020 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Estados Unidos