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Chemical Composition and Anti-Alzheimer's Disease-Related Activities of a Functional Oil from the Edible Seaweed Hizikia fusiforme.
Yang, Wen-Cong; Zhang, Yuan-Yuan; Li, Ya-Juan; Nie, Ying-Ying; Liang, Jin-Yue; Liu, Ya-Yue; Liu, Jing-Shan; Zhang, Yong-Ping; Song, Cai; Qian, Zhong-Ji; Zhang, Yi.
Afiliación
  • Yang WC; Shenzhen Research Institute of Guangdong Ocean University, Shenzhen, 518120, P. R. China.
  • Zhang YY; College of Food Science and Technology, Guangdong Ocean University, Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety, Guangdong Province Engineering Laboratory for Marine Biological Products, Research Institute for Marine Drugs and Nutrition, Guangdong Ocean University, Z
  • Li YJ; School of Chemistry, Sun Yat-Sen University, Guangzhou, 510275, P. R. China.
  • Nie YY; Shenzhen Research Institute of Guangdong Ocean University, Shenzhen, 518120, P. R. China.
  • Liang JY; College of Food Science and Technology, Guangdong Ocean University, Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety, Guangdong Province Engineering Laboratory for Marine Biological Products, Research Institute for Marine Drugs and Nutrition, Guangdong Ocean University, Z
  • Liu YY; College of Food Science and Technology, Guangdong Ocean University, Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety, Guangdong Province Engineering Laboratory for Marine Biological Products, Research Institute for Marine Drugs and Nutrition, Guangdong Ocean University, Z
  • Liu JS; College of Food Science and Technology, Guangdong Ocean University, Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety, Guangdong Province Engineering Laboratory for Marine Biological Products, Research Institute for Marine Drugs and Nutrition, Guangdong Ocean University, Z
  • Zhang YP; Shenzhen Research Institute of Guangdong Ocean University, Shenzhen, 518120, P. R. China.
  • Song C; College of Food Science and Technology, Guangdong Ocean University, Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety, Guangdong Province Engineering Laboratory for Marine Biological Products, Research Institute for Marine Drugs and Nutrition, Guangdong Ocean University, Z
  • Qian ZJ; Shenzhen Research Institute of Guangdong Ocean University, Shenzhen, 518120, P. R. China.
  • Zhang Y; College of Food Science and Technology, Guangdong Ocean University, Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety, Guangdong Province Engineering Laboratory for Marine Biological Products, Research Institute for Marine Drugs and Nutrition, Guangdong Ocean University, Z
Chem Biodivers ; 17(8): e2000055, 2020 Aug.
Article en En | MEDLINE | ID: mdl-32419273
Cholinergic disorder, oxidative stress, and neuroinflammation play important roles in the pathology of Alzheimer's disease. To explore the healthy potential of the edible seaweed Hizikia fusiforme on this aspect, a functional oil (HFFO) was extracted from this alga and investigated on its constituents by gas chromatography-mass spectrometry (GC/MS) in this study. Its anti-Alzheimer's related bioactivities including acetylcholinesterase (AChE) inhibition, antioxidation, and anti-neuroinflammation were evaluated, traced, and simulated by in vitro and in silico methods. GC/MS analysis indicated that HFFO mainly contained arachidonic acid (ARA), 11,14,17-eicosatrienoic acid (ETrA), palmitic acid, phytol, etc. HFFO showed moderate AChE inhibition and antioxidant activity. Bioactivity tracing using commercial standards verified that AChE inhibition of HFFO mainly originated from ARA and ETrA, whereas antioxidant activity mainly from ARA. Lineweaver-Burk plots showed that both ARA and ETrA are noncompetitive AChE inhibitors. A molecular docking study demonstrated low CDOCKER interaction energy of -26.33 kcal/mol for ARA and -43.70 kcal/mol for ETrA when interacting with AChE and multiple interactions in the ARA (or ETrA)-AChE complex. In the anti-neuroinflammatory evaluation, HFFO showed no toxicity toward BV-2 cells at 20 µg/mL and effectively inhibited the production of nitroxide and reduced the level of reactive oxygen species in lipopolysaccharide-induced BV-2 cells. The results indicated that HFFO could be used in functional foods for its anti-Alzheimer's disease-related activities.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Algas Marinas / Aceites de Plantas / Enfermedad de Alzheimer Límite: Humans Idioma: En Revista: Chem Biodivers Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2020 Tipo del documento: Article Pais de publicación: Suiza
Texto completo
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Imprimir
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Algas Marinas / Aceites de Plantas / Enfermedad de Alzheimer Límite: Humans Idioma: En Revista: Chem Biodivers Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2020 Tipo del documento: Article Pais de publicación: Suiza