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Survey and Diagnostic Challenges after Transmission-Stop: Confirming Elimination of Schistosomiasis haematobium in Morocco.
Fatima, Amarir; Abdelaali, Balahbib; Corstjens, Paul L A M; Abderrahim, Sadak; El Bachir, Adlaoui; Mohamed, Rhajaoui.
Afiliación
  • Fatima A; Department of Parasitology, National Reference Laboratory for Schistosomiasis and Malacology, National Institute of Hygiene, Agdal, Rabat, Morocco.
  • Abdelaali B; Department of Biology, Laboratory of Immunology and Biodiversity, Faculty of Sciences Ain Chock, University Hassan II, Casablanca, Morocco.
  • Corstjens PLAM; Department of Parasitology, National Reference Laboratory for Schistosomiasis and Malacology, National Institute of Hygiene, Agdal, Rabat, Morocco.
  • Abderrahim S; Laboratory of Zoology and General Biology, Faculty of Sciences, Mohammed V University in Rabat, Morocco.
  • El Bachir A; Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, Netherlands.
  • Mohamed R; Laboratory of Zoology and General Biology, Faculty of Sciences, Mohammed V University in Rabat, Morocco.
J Parasitol Res ; 2020: 9705358, 2020.
Article en En | MEDLINE | ID: mdl-32411424
Clinical cases of Moroccan residents have been recorded since 2004, indicating successful interruption of transmission of S. haematobium infection at national level. The first national survey initiated in 2009 for Schistosomiasis haematobium among children born after 2004, applied diagnostic test was the HAMA-EITB, based on the Western blot technology, and molecular malacological diagnostic tools clearly confirm transmission stop. In 2015, a recent, small survey utilizing an HAI, ELISA tests and an ultrasensitive antigen test, FTCUP CAA, in a group of individual with a past history of infection. However, obviously follow-up surveys to prevent reemergency and for certification of the schistosomiasis elimination require vigilant diagnosis strategies. Here we discuss diagnosis story line in the national laboratory and challenges based on the available tools in relation to their clinical parameters (sensitivity/specificity; Sn/Sp), practicability and associated costs. When transmission stop has been achieved, survey cost and speed are likely to benefit from cost effective pooling strategies and ultrasensitive assays indicating active infection in all potential risk groups. Similarly molecular pooling strategies to monitor infections in the snail vectors.

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Parasitol Res Año: 2020 Tipo del documento: Article País de afiliación: Marruecos Pais de publicación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Parasitol Res Año: 2020 Tipo del documento: Article País de afiliación: Marruecos Pais de publicación: Estados Unidos