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A Forgotten Episode of Marburg Virus Disease: Belgrade, Yugoslavia, 1967.
Ristanovic, Elizabeta S; Kokoskov, Nenad S; Crozier, Ian; Kuhn, Jens H; Gligic, Ana S.
Afiliación
  • Ristanovic ES; Military Medical Academy, University of Defence, Belgrade, Serbia.
  • Kokoskov NS; Academy of National Security, Belgrade, Serbia.
  • Crozier I; Integrated Research Facility at Fort Detrick, Clinical Monitoring Research Program Directorate, Frederick National Laboratory for Cancer Research supported by the National Cancer Institute, Frederick, Maryland, USA.
  • Kuhn JH; Integrated Research Facility at Fort Detrick, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, Maryland, USA kuhnjens@mail.nih.gov drgligicana@gmail.com.
  • Gligic AS; Institute of Virology, Vaccines and Sera "Torlak," Belgrade, Serbia kuhnjens@mail.nih.gov drgligicana@gmail.com.
Microbiol Mol Biol Rev ; 84(2)2020 05 20.
Article en En | MEDLINE | ID: mdl-32404328
In 1967, several workers involved in poliomyelitis vaccine development and production fell ill at three different locations in Europe with a severe and often lethal novel disease associated with grivets (Chlorocebus aethiops) imported from Uganda. This disease was named Marburg virus disease (MVD) after the West German town of Marburg an der Lahn, where most human infections and deaths had been recorded. Consequently, the Marburg episode received the most scientific and media attention. Cases that occurred in Frankfurt am Main, West Germany, were also described in commonly accessible scientific literature, although they were less frequently cited than those pertaining to the Marburg infections. However, two infections occurring in a third location, in Belgrade, Yugoslavia, have seemingly been all but forgotten. Due in part to their absence in commonly used databases and in part to the fact that they were written in languages other than English, the important articles describing this part of the outbreak are very rarely cited. Here, we summarize this literature and correct published inaccuracies to remind a younger generation of scientists focusing on Marburg virus and its closest filoviral relatives of this important historical context. Importantly, and unfortunately, the three episodes of infection of 1967 still represent the best in-depth clinical look at MVD in general and in the context of "modern" medicine (fully resourced versus less-resourced capacity) in particular. Hence, each individual case of these episodes holds crucial information for health care providers who may be confronted with MVD today.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Chlorocebus aethiops / Brotes de Enfermedades / Infección de Laboratorio / Enfermedad del Virus de Marburg Límite: Animals / Humans País/Región como asunto: Africa Idioma: En Revista: Microbiol Mol Biol Rev Asunto de la revista: BIOLOGIA MOLECULAR / MICROBIOLOGIA Año: 2020 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Chlorocebus aethiops / Brotes de Enfermedades / Infección de Laboratorio / Enfermedad del Virus de Marburg Límite: Animals / Humans País/Región como asunto: Africa Idioma: En Revista: Microbiol Mol Biol Rev Asunto de la revista: BIOLOGIA MOLECULAR / MICROBIOLOGIA Año: 2020 Tipo del documento: Article Pais de publicación: Estados Unidos