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Interlimb conditioning of lumbosacral spinally evoked motor responses after spinal cord injury.
Atkinson, D A; Sayenko, D G; D'Amico, J M; Mink, A; Lorenz, D J; Gerasimenko, Y P; Harkema, S.
Afiliación
  • Atkinson DA; University of St. Augustine for Health Sciences, Austin, TX, USA.
  • Sayenko DG; Department of Neurosurgery, Center for Neuroregeneration, Houston Methodist Hospital, Houston, TX, USA.
  • D'Amico JM; Neuroscience Collaborative Center, Frazier Rehab Institute, Louisville, KY, USA; Kentucky Spinal Cord Injury Research Center, University of Louisville, Louisville, KY, USA; Department of Neurological Surgery, University of Louisville, Louisville, KY, USA.
  • Mink A; Neuroscience Collaborative Center, Frazier Rehab Institute, Louisville, KY, USA; Kentucky Spinal Cord Injury Research Center, University of Louisville, Louisville, KY, USA; Department of Physiology and Biophysics, University of Louisville, Louisville, KY, USA.
  • Lorenz DJ; Department of Bioinformatics and Biostatistics, University of Louisville, Louisville, KY, USA.
  • Gerasimenko YP; Kentucky Spinal Cord Injury Research Center, University of Louisville, Louisville, KY, USA; Department of Physiology and Biophysics, University of Louisville, Louisville, KY, USA; Pavlov Institute of Physiology, St. Petersburg, Russia.
  • Harkema S; Neuroscience Collaborative Center, Frazier Rehab Institute, Louisville, KY, USA; Kentucky Spinal Cord Injury Research Center, University of Louisville, Louisville, KY, USA; Department of Neurological Surgery, University of Louisville, Louisville, KY, USA. Electronic address: susan.harkema@louisville
Clin Neurophysiol ; 131(7): 1519-1532, 2020 07.
Article en En | MEDLINE | ID: mdl-32403065
OBJECTIVE: The importance of subcortical pathways to functional motor recovery after spinal cord injury (SCI) has been demonstrated in multiple animal models. The current study evaluated descending interlimb influence on lumbosacral motor excitability after chronic SCI in humans. METHODS: Ulnar nerve stimulation and transcutaneous electrical spinal stimulation were used in a condition-test paradigm to evaluate the presence of interlimb connections linking the cervical and lumbosacral spinal segments in non-injured (n=15) and spinal cord injured (SCI) (n=18) participants. RESULTS: Potentiation of spinally evoked motor responses (sEMRs) by ulnar nerve conditioning was observed in 7/7 SCI participants with volitional leg muscle activation, and in 6/11 SCI participants with no volitional activation. Of these six, conditioning of sEMRs was present only when the neurological level of injury was rostral to the ulnar innervation entry zones. CONCLUSIONS: Descending modulation of lumbosacral motor pools via interlimb projections may exist in SCI participants despite the absence of volitional leg muscle activation. SIGNIFICANCE: Evaluation of sub-clinical, spared pathways within the spinal cord after SCI may provide an improved understanding of both the contributions of different pathways to residual function, and the mechanisms of plasticity and functional motor recovery following rehabilitation..
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Traumatismos de la Médula Espinal / Estimulación Eléctrica Transcutánea del Nervio / Potenciales Evocados Motores / Extremidades / Estimulación de la Médula Espinal Límite: Adult / Female / Humans / Male Idioma: En Revista: Clin Neurophysiol Asunto de la revista: NEUROLOGIA / PSICOFISIOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Traumatismos de la Médula Espinal / Estimulación Eléctrica Transcutánea del Nervio / Potenciales Evocados Motores / Extremidades / Estimulación de la Médula Espinal Límite: Adult / Female / Humans / Male Idioma: En Revista: Clin Neurophysiol Asunto de la revista: NEUROLOGIA / PSICOFISIOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Países Bajos