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Occupational exposure to organophosphate pesticides and hematologic neoplasms: a systematic review. / Exposição ocupacional a agrotóxicos organofosforados e neoplasias hematológicas: uma revisão sistemática.
Moura, Luiza Taciana Rodrigues de; Bedor, Cheila Nataly Galindo; Lopez, Rossana Veronica Mendoza; Santana, Vilma Sousa; Rocha, Talita Máira Bueno da Silveira da; Wünsch Filho, Victor; Curado, Maria Paula.
Afiliación
  • Moura LTR; Universidade Federal do Vale do São Francisco, Petrolina, PE, Brazil.
  • Bedor CNG; Universidade Federal do Vale do São Francisco, Petrolina, PE, Brazil.
  • Lopez RVM; Centro de Investigação Translacional em Oncologia, Instituto do Câncer do Estado de São Paulo, São Paulo, SP, Brasil.
  • Santana VS; Programa Integrado em Saúde Ambiental e do Trabalhador, Instituto de Saúde Coletiva, Universidade Federal da Bahia, Salvador, BA, Brazil.
  • Rocha TMBDSD; Fundação Antônio Prudente, A.C. Camargo Cancer Center, São Paulo, SP, Brazil.
  • Wünsch Filho V; Departamento de Epidemiologia, Faculdade de Saúde Pública, Universidade de São Paulo, São Paulo, SP, Brazil.
  • Curado MP; Fundação Antônio Prudente, A.C. Camargo Cancer Center, São Paulo, SP, Brazil.
Rev Bras Epidemiol ; 23: e200022, 2020.
Article en En, Pt | MEDLINE | ID: mdl-32401913
OBJECTIVE: To update findings of observational analytical studies on the association between occupational exposure to organophosphates and hematologic malignancies. METHODOLOGY: Systematic literature review, including cohort and case-control studies, without limitation of publication time, in Portuguese and English. The articles were traced from June 2017 to July 2019 in PubMed, MEDLINE, LILACS, Web of Science, and Scopus databases. The qualitative bias risk assessment was performed using the Newcastle-Ottawa Scale and the Downs and Black Checklist. Results were presented according to the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA). RESULTS: Seventeen studies evaluated as good/high methodological quality were eligible. Exposure to diazinon (1 cohort), phonophos (1 cohort), dichlorvos, crotoxiphos and famphur (1 case control) was associated with leukemia, while exposure to organophosphate was associated to lymphomas (6 case control); the risk of non-Hodgkin's lymphoma was higher in those exposed to diazinon (1 control case) and malathion (3 control case) than non-exposed ones. Multiple myeloma occurred more commonly in organophosphate exposed than in non-exposed individuals (1 case-control). CONCLUSION: Occupational exposure to organophosphates increases the risk of hematologic malignancies, especially among individuals with longer exposure periods. Worker monitoring and exposure control measures are recommended.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Plaguicidas / Exposición Profesional / Neoplasias Hematológicas / Intoxicación por Organofosfatos Tipo de estudio: Etiology_studies / Observational_studies / Qualitative_research / Risk_factors_studies / Systematic_reviews Límite: Humans Idioma: En / Pt Revista: Rev Bras Epidemiol Asunto de la revista: EPIDEMIOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Brasil
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Plaguicidas / Exposición Profesional / Neoplasias Hematológicas / Intoxicación por Organofosfatos Tipo de estudio: Etiology_studies / Observational_studies / Qualitative_research / Risk_factors_studies / Systematic_reviews Límite: Humans Idioma: En / Pt Revista: Rev Bras Epidemiol Asunto de la revista: EPIDEMIOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Brasil