Ulcerative colitis: Recent advances in the understanding of disease pathogenesis.

Porter, Ross J; Kalla, Rahul; Ho, Gwo-Tzer

Porter, Ross J; Kalla, Rahul; Ho, Gwo-Tzer.

Afiliación

Porter RJ; Edinburgh IBD Science Unit, Centre for Inflammation Research, Queens Medical Research Unit, University of Edinburgh, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK.
Kalla R; Edinburgh IBD Science Unit, Centre for Inflammation Research, Queens Medical Research Unit, University of Edinburgh, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK.
Ho GT; Edinburgh IBD Science Unit, Centre for Inflammation Research, Queens Medical Research Unit, University of Edinburgh, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK.

F1000Res ; 92020.

Article en En | MEDLINE | ID: mdl-32399194

RESUMEN

Inflammatory bowel diseases are common, complex, immune-mediated conditions with a sharply rising global prevalence. While major advances since 2000 have provided strong mechanistic clues implicating a de-regulation in the normal interaction among host genetics, immunity, microbiome, and the environment, more recent progress has generated entirely new hypotheses and also further refined older disease concepts. In this review, we focus specifically on these novel developments in the pathogenesis of ulcerative colitis.

Asunto(s)

Colitis Ulcerosa/fisiopatología; Colitis Ulcerosa/genética; Femenino; Humanos; Inmunidad; Masculino; Microbiota

Palabras clave

Inflammation; Inflammatory Bowel Disease; Mucosal Immunology; Pathogenesis; Ulcerative colitis

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Colitis Ulcerosa Tipo de estudio: Etiology_studies / Risk_factors_studies Límite: Female / Humans / Male Idioma: En Revista: F1000Res Año: 2020 Tipo del documento: Article Pais de publicación: Reino Unido

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