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Inhibitory Effects of Carrageenans on Endotoxin-Induced Inflammation.
Yermak, Irina M; Volod'ko, Aleksandra V; Khasina, Eleonora I; Davydova, Viktoriya N; Chusovitin, Evgeniy A; Goroshko, Dmitry L; Kravchenko, Anna O; Solov'eva, Tamara F; Maleev, Victor V.
Afiliación
  • Yermak IM; G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch, Russian Academy of Sciences, Prospect 100 let Vladivostoku 159, Vladivostok 690022, Russia.
  • Volod'ko AV; G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch, Russian Academy of Sciences, Prospect 100 let Vladivostoku 159, Vladivostok 690022, Russia.
  • Khasina EI; Federal Scientific Center of the East Asia Terrestrial Biodiversity, Far Eastern Branch, Russian Academy of Sciences, Prospect 100 let Vladivostoku 159, Vladivostok 690022, Russia.
  • Davydova VN; G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch, Russian Academy of Sciences, Prospect 100 let Vladivostoku 159, Vladivostok 690022, Russia.
  • Chusovitin EA; Institute for Automation and Control Processes, Far Eastern Branch, Russian Academy of Sciences, 5 Radio St., Vladivostok 690041, Russia.
  • Goroshko DL; Institute for Automation and Control Processes, Far Eastern Branch, Russian Academy of Sciences, 5 Radio St., Vladivostok 690041, Russia.
  • Kravchenko AO; Far Eastern Federal University, 8 Sukhanova St., Vladivostok 690950, Russia.
  • Solov'eva TF; G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch, Russian Academy of Sciences, Prospect 100 let Vladivostoku 159, Vladivostok 690022, Russia.
  • Maleev VV; G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch, Russian Academy of Sciences, Prospect 100 let Vladivostoku 159, Vladivostok 690022, Russia.
Mar Drugs ; 18(5)2020 May 10.
Article en En | MEDLINE | ID: mdl-32397584
The inhibitory effects of carrageenans (CRGs) on lipopolysaccharide (LPS) induced inflammation in a mouse model of endotoxemia and in complex therapy of patients with enteric infections of Salmonella etiology were studied. The atomic force microscopy (AFM) examination of LPS and its mixture with CRGs showed that the LPS morphology is significantly changed under the action of κ- and κ/ß-CRGs. CRGs were able to increase the synthesis of anti-inflammatory interleukin 10 (IL-10) in vitro, and, at low concentrations, their activity in the mixture with LPS was higher. The protective effect of CRGs against Escherichia coli LPS was studied in vivo by monitoring the biochemical and pathomorphological parameters. The κ- and κ/ß-CRGs and food supplement "Carrageenan-FE" increased the nonspecific resistance of mice to E. coli LPS at the expense of the inhibition of processes of thymus involution, adrenals hypertrophy, thyroid atrophy, hypercorticoidism, glycogenolysis, and lactate acidosis. The estimation of the therapeutic action of food supplement Carrageenan-FE in complex therapy of patients with enteric infections of Salmonella etiology is given. Carrageenan-FE restores the system of hemostasis and corrects some biochemical indicators and parameters in the immune systems of patients. These results allow us to hope for the practical application of CRGs for lowering the endotoxemia level in patients under the development of the infectious process caused by Gram-negative bacteria.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Intoxicación Alimentaria por Salmonella / Carragenina / Endotoxemia / Suplementos Dietéticos / Infecciones por Escherichia coli Límite: Animals / Humans / Male Idioma: En Revista: Mar Drugs Asunto de la revista: BIOLOGIA / FARMACOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: Rusia Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Intoxicación Alimentaria por Salmonella / Carragenina / Endotoxemia / Suplementos Dietéticos / Infecciones por Escherichia coli Límite: Animals / Humans / Male Idioma: En Revista: Mar Drugs Asunto de la revista: BIOLOGIA / FARMACOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: Rusia Pais de publicación: Suiza