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Neurologic, clinical, and immunologic features in a cohort of HTLV-1 carriers with high proviral loads.
Ferraz, Sheila N; Costa, Gabriela F; Carneiro Neto, José Abraão; Hebert, Thiago; de Oliveira, Cassius J V; Guerra, Mariele; Oliveira, Lívia M A; Carvalho, Edgar M.
Afiliación
  • Ferraz SN; Immunology Service, Professor Edgard Santos University Hospital, Federal University of Bahia, Salvador, Brazil.
  • Costa GF; Escola Bahiana de Medicina e Saúde Pública, Salvador, Bahia, Brazil.
  • Carneiro Neto JA; Immunology Service, Professor Edgard Santos University Hospital, Federal University of Bahia, Salvador, Brazil.
  • Hebert T; Escola Bahiana de Medicina e Saúde Pública, Salvador, Bahia, Brazil.
  • de Oliveira CJV; Immunology Service, Professor Edgard Santos University Hospital, Federal University of Bahia, Salvador, Brazil.
  • Guerra M; Immunology Service, Professor Edgard Santos University Hospital, Federal University of Bahia, Salvador, Brazil.
  • Oliveira LMA; Immunology Service, Professor Edgard Santos University Hospital, Federal University of Bahia, Salvador, Brazil.
  • Carvalho EM; Immunology Service, Professor Edgard Santos University Hospital, Federal University of Bahia, Salvador, Brazil. imuno@ufba.br.
J Neurovirol ; 26(4): 520-529, 2020 08.
Article en En | MEDLINE | ID: mdl-32385802
A high proviral load (PVL) is recognized as a risk factor for human T cell leukemia virus-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), but there is a lack of prospective studies evaluating whether or not HTLV-1 carriers with high PVL are at risk of developing HAM/TSP or other HTLV-1-related diseases. Here, we compare the incidence of clinical manifestations and the cytokine levels in 30 HTLV-1 carriers with high (> 50,000 copies/106 PBMC) and an equal number of subjects with low proviral load. Participants were followed for 3 to 16 years (median of 11 years). The PVL, IFN-γ, TNF, and IL-10 levels were quantified at entry and at the end of the follow-up. Among the self-reported symptoms in the initial evaluation, only the presence of paresthesia on the hands was more frequent in the group with high PVL (p < 0.04). The production of IFN-γ was higher in the group with high PVL group (median of 1308 versus 686 pg/ml, p < 0.011) when compared with the control group in the first assessment. There was no difference in the occurrence of urinary symptoms or erectile dysfunction, periodontal disease, Sicca syndrome, and neurologic signs between the two groups during the follow-up. The observation that none of the HTLV-1 carriers with high PVL and with exaggerated inflammatory response progressed to HAM/TSP indicates that other factors in addition to the PVL and an exaggerated immune response are involved in the pathogenesis of HAM/TSP.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Leucocitos Mononucleares / Virus Linfotrópico T Tipo 1 Humano / Infecciones por HTLV-I / Portador Sano / Provirus Tipo de estudio: Diagnostic_studies / Observational_studies / Risk_factors_studies Idioma: En Revista: J Neurovirol Asunto de la revista: NEUROLOGIA / VIROLOGIA Año: 2020 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Leucocitos Mononucleares / Virus Linfotrópico T Tipo 1 Humano / Infecciones por HTLV-I / Portador Sano / Provirus Tipo de estudio: Diagnostic_studies / Observational_studies / Risk_factors_studies Idioma: En Revista: J Neurovirol Asunto de la revista: NEUROLOGIA / VIROLOGIA Año: 2020 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Estados Unidos