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Human cord blood-derived regulatory T-cell therapy modulates the central and peripheral immune response after traumatic brain injury.
Caplan, Henry W; Prabhakara, Karthik S; Kumar, Akshita; Toledano-Furman, Naama E; Martin, Cecilia; Carrillo, Louis; Moreno, Nicolas F; Bordt, Andrea S; Olson, Scott D; Cox, Charles S.
Afiliación
  • Caplan HW; Department of Pediatric Surgery, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, Texas, USA.
  • Prabhakara KS; Department of Pediatric Surgery, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, Texas, USA.
  • Kumar A; Department of Pediatric Surgery, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, Texas, USA.
  • Toledano-Furman NE; Department of Pediatric Surgery, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, Texas, USA.
  • Martin C; Department of Pediatric Surgery, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, Texas, USA.
  • Carrillo L; Department of Pediatric Surgery, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, Texas, USA.
  • Moreno NF; Department of Pediatric Surgery, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, Texas, USA.
  • Bordt AS; Department of Pediatric Surgery, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, Texas, USA.
  • Olson SD; Department of Pediatric Surgery, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, Texas, USA.
  • Cox CS; Department of Pediatric Surgery, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, Texas, USA.
Stem Cells Transl Med ; 9(8): 903-916, 2020 08.
Article en En | MEDLINE | ID: mdl-32383348
Traumatic brain injury (TBI) causes a profound inflammatory response within the central nervous system and peripheral immune system, which contributes to secondary brain injury and further morbidity and mortality. Preclinical investigations have demonstrated that treatments that downregulate microglia activation and polarize them toward a reparative/anti-inflammatory phenotype have improved outcomes in preclinical models. However, no therapy to date has translated into proven benefits in human patients. Regulatory T cells (Treg) have been shown to downregulate pathologic immune responses of the innate and adaptive immune system across a variety of pathologies. Furthermore, cellular therapy has been shown to augment host Treg responses in preclinical models; yet, studies investigating the use of Treg as a therapeutic for TBI are lacking. In a rodent TBI model, we demonstrate that human umbilical cord blood Treg modulate the central and peripheral immune response after injury in vitro and in vivo.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Inmunofenotipificación / Linfocitos T Reguladores / Tratamiento Basado en Trasplante de Células y Tejidos / Lesiones Traumáticas del Encéfalo / Inmunidad Límite: Animals / Humans Idioma: En Revista: Stem Cells Transl Med Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Inmunofenotipificación / Linfocitos T Reguladores / Tratamiento Basado en Trasplante de Células y Tejidos / Lesiones Traumáticas del Encéfalo / Inmunidad Límite: Animals / Humans Idioma: En Revista: Stem Cells Transl Med Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido