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Data supporting the effects of xanthine derivative KMUP-3 on vascular smooth muscle cell calcification and abdominal aortic aneurysm in mice.
Lai, Chao-Han; Chang, Ching-Wen; Lee, Fang-Tzu; Kuo, Cheng-Hsiang; Hsu, Jong-Hau; Liu, Chung-Pin; Wu, Hua-Lin; Yeh, Jwu-Lai.
Afiliación
  • Lai CH; Department of Surgery, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
  • Chang CW; Cardiovascular Research Center, National Cheng Kung University, Tainan, Taiwan.
  • Lee FT; Department of Pharmacology, School of Medicine, College of Medicine, Kaohsiung Medical University, 100 Shih-Chuan First Road, Kaohsiung, Taiwan.
  • Kuo CH; Department of Surgery, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
  • Hsu JH; Cardiovascular Research Center, National Cheng Kung University, Tainan, Taiwan.
  • Liu CP; Department of Biochemistry and Molecular Biology, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
  • Wu HL; Cardiovascular Research Center, National Cheng Kung University, Tainan, Taiwan.
  • Yeh JL; Department of Biochemistry and Molecular Biology, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Data Brief ; 30: 105550, 2020 Jun.
Article en En | MEDLINE | ID: mdl-32382597
No pharmacotherapy in the clinical setting has been available to alter the natural history of abdominal aortic aneurysm (AAA). Targeting vascular smooth muscle cell (VSMC) dysfunction during the pathogenesis of AAA, including phenotypic switch and apoptosis, could be a potential strategy to limit AAA growth. Here, we provide additional information regarding materials, methods and data related to our recent study published in Atherosclerosis [1]. The therapeutic potential of a self-developed xanthine derivative KMUP-3 was evaluated in VSMC calcification and abdominal aortic aneurysm (AAA). In vitro VSMC calcification was induced using ß-glycerophosphate, and AAA was induced using angiotensin II infusion for 4 weeks in apolipoprotein E-deficient mice. The data contained in this article support the effects of KMUP-3 on VSMC calcification and AAA.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Data Brief Año: 2020 Tipo del documento: Article País de afiliación: Taiwán Pais de publicación: Países Bajos
Texto completo
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PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Data Brief Año: 2020 Tipo del documento: Article País de afiliación: Taiwán Pais de publicación: Países Bajos