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The untapped potential of ascites in ovarian cancer research and treatment.
Ford, Caroline Elizabeth; Werner, Bonnita; Hacker, Neville Frederick; Warton, Kristina.
Afiliación
  • Ford CE; Gynaecological Cancer Research Group, Lowy Cancer Research Centre and School of Women's and Children's Health, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia. caroline.ford@unsw.edu.au.
  • Werner B; Gynaecological Cancer Research Group, Lowy Cancer Research Centre and School of Women's and Children's Health, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia.
  • Hacker NF; Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia.
  • Warton K; Gynaecological Cancer Research Group, Lowy Cancer Research Centre and School of Women's and Children's Health, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia.
Br J Cancer ; 123(1): 9-16, 2020 07.
Article en En | MEDLINE | ID: mdl-32382112
The build-up of fluid in the peritoneal cavity-ascites-is a hallmark of ovarian cancer, the most lethal of all gynaecological malignancies. This remarkable fluid, which contains a variety of cellular and acellular components, is known to contribute to patient morbidity and mortality by facilitating metastasis and contributing to chemoresistance, but remains largely under-researched. In this review, we will critically analyse the evidence associating ascites with metastasis and chemoresistance in ovarian cancer and provide an update on research in the field. We will argue the case for ascites as a unique and accessible substrate for tracking tumour progression and for translational research that will enhance our understanding of this cancer and lead to improvements in patient outcomes.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Ováricas / Ascitis / Biomarcadores de Tumor / Proteómica Tipo de estudio: Diagnostic_studies Límite: Female / Humans Idioma: En Revista: Br J Cancer Año: 2020 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Ováricas / Ascitis / Biomarcadores de Tumor / Proteómica Tipo de estudio: Diagnostic_studies Límite: Female / Humans Idioma: En Revista: Br J Cancer Año: 2020 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Reino Unido