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FDA-approved disulfiram inhibits pyroptosis by blocking gasdermin D pore formation.
Hu, Jun Jacob; Liu, Xing; Xia, Shiyu; Zhang, Zhibin; Zhang, Ying; Zhao, Jingxia; Ruan, Jianbin; Luo, Xuemei; Lou, Xiwen; Bai, Yang; Wang, Junhong; Hollingsworth, L Robert; Magupalli, Venkat Giri; Zhao, Li; Luo, Hongbo R; Kim, Justin; Lieberman, Judy; Wu, Hao.
Afiliación
  • Hu JJ; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.
  • Liu X; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.
  • Xia S; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA. xingliu@ips.ac.cn.
  • Zhang Z; Department of Pediatrics, Harvard Medical School, Boston, MA, USA. xingliu@ips.ac.cn.
  • Zhang Y; The Center for Microbes, Development and Health, Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, China. xingliu@ips.ac.cn.
  • Zhao J; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.
  • Ruan J; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.
  • Luo X; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.
  • Lou X; Department of Pediatrics, Harvard Medical School, Boston, MA, USA.
  • Bai Y; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.
  • Wang J; Department of Pediatrics, Harvard Medical School, Boston, MA, USA.
  • Hollingsworth LR; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.
  • Magupalli VG; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.
  • Zhao L; Beijing Institute of Traditional Chinese Medicine, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing, China.
  • Luo HR; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.
  • Kim J; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.
  • Lieberman J; Department of Immunology, University of Connecticut Health Center, Farmington, CT, USA.
  • Wu H; Biomolecular Resource Facility, University of Texas Medical Branch, Galveston, TX, USA.
Nat Immunol ; 21(7): 736-745, 2020 07.
Article en En | MEDLINE | ID: mdl-32367036
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sepsis / Proteínas de Unión a Fosfato / Péptidos y Proteínas de Señalización Intracelular / Disulfiram / Piroptosis Idioma: En Revista: Nat Immunol Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sepsis / Proteínas de Unión a Fosfato / Péptidos y Proteínas de Señalización Intracelular / Disulfiram / Piroptosis Idioma: En Revista: Nat Immunol Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos