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The relationship between cingulum bundle integrity and different aspects of executive functions in chronic schizophrenia.
Tyburski, Ernest; Mak, Monika; Samochowiec, Agnieszka; Plichta, Piotr; Bielecki, Maksymilian; Rek-Owodzin, Katarzyna; Podwalski, Piotr; Rudkowski, Krzysztof; Waszczuk, Katarzyna; Pelka-Wysiecka, Justyna; Kucharska-Mazur, Jolanta; Andrusewicz, Wojciech; Misiak, Blazej; Kerestey, Magdalena; Michalczyk, Anna; Mueller, Shane T; Sagan, Leszek; Samochowiec, Jerzy.
Afiliación
  • Tyburski E; Institute of Psychology, SWPS University of Social Sciences and Humanities, Poznan, Poland.
  • Mak M; Independent Clinical Psychology Unit, Pomeranian Medical University, Szczecin, Poland.
  • Samochowiec A; Institute of Psychology, University of Szczecin, Szczecin, Poland.
  • Plichta P; Independent Clinical Psychology Unit, Pomeranian Medical University, Szczecin, Poland.
  • Bielecki M; Independent Clinical Psychology Unit, Pomeranian Medical University, Szczecin, Poland.
  • Rek-Owodzin K; Independent Clinical Psychology Unit, Pomeranian Medical University, Szczecin, Poland.
  • Podwalski P; Department of Psychiatry, Pomeranian Medical University, Szczecin, Poland.
  • Rudkowski K; Department of Psychiatry, Pomeranian Medical University, Szczecin, Poland.
  • Waszczuk K; Department of Psychiatry, Pomeranian Medical University, Szczecin, Poland.
  • Pelka-Wysiecka J; Department of Psychiatry, Pomeranian Medical University, Szczecin, Poland.
  • Kucharska-Mazur J; Department of Psychiatry, Pomeranian Medical University, Szczecin, Poland.
  • Andrusewicz W; Department of Neurosurgery, Pomeranian Medical University, Szczecin, Poland.
  • Misiak B; Department of Genetics, Wroclaw Medical University, Wroclaw, Poland.
  • Kerestey M; Institute of Psychology, University of Szczecin, Szczecin, Poland.
  • Michalczyk A; Department of Psychiatry, Pomeranian Medical University, Szczecin, Poland.
  • Mueller ST; Department of Cognitive and Learning Sciences, Michigan Technological University, MI, USA.
  • Sagan L; Department of Neurosurgery, Pomeranian Medical University, Szczecin, Poland.
  • Samochowiec J; Department of Psychiatry, Pomeranian Medical University, Szczecin, Poland. Electronic address: samoj@pum.edu.pl.
Prog Neuropsychopharmacol Biol Psychiatry ; 102: 109955, 2020 08 30.
Article en En | MEDLINE | ID: mdl-32360815
BACKGROUND: Evidence suggests that disruption in the cingulum bundle (CB) may influence executive dysfunctions in schizophrenia, but findings are still inconsistent. Using diffusion tensor imaging tractography, we investigated the differences in fiber integrity between schizophrenia patients and healthy controls together with the association between fiber integrity and executive functions. METHODS: Thirty-two patients with chronic schizophrenia and 24 healthy controls took part in the study. Both groups were matched for age, sex, and years of education. Assessment of cognitive functions was performed using the Berg Card Sorting Test (BCST), the Color Trail Test (CTT), and the Stroop Color-Word Test (SCWT). RESULTS: Results showed group differences, bilaterally (left and right) in fractional anisotropy (FA) of the CB, where patients showed less anisotropy than controls. Moreover, normal asymmetry (left FA > right FA) in the CB in schizophrenia was found. There were no group differences in mean diffusivity (MD). Patients had a similar but reduced profile of executive functions compared to healthy controls. However, when premorbid IQ was controlled for, the differences were no longer statistically significant. In schizophrenia patients, a negative correlation was found between FA of the left CB and perseverative errors in the BCST. CONCLUSIONS: These findings provide evidence that CB disruption appears in schizophrenia patients and might account for impairments of executive processes, including concept formation.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Esquizofrenia / Psicología del Esquizofrénico / Función Ejecutiva / Giro del Cíngulo Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Prog Neuropsychopharmacol Biol Psychiatry Año: 2020 Tipo del documento: Article País de afiliación: Polonia Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Esquizofrenia / Psicología del Esquizofrénico / Función Ejecutiva / Giro del Cíngulo Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Prog Neuropsychopharmacol Biol Psychiatry Año: 2020 Tipo del documento: Article País de afiliación: Polonia Pais de publicación: Reino Unido