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Re-irradiation With Carbon Ion Radiotherapy for Pelvic Rectal Cancer Recurrences in Patients Previously Irradiated to the Pelvis.
Barcellini, Amelia; Vitolo, Viviana; Cobianchi, Lorenzo; Peloso, Andrea; Vanoli, Alessandro; Mirandola, Alfredo; Facoetti, Angelica; Fiore, Maria Rosaria; Iannalfi, Alberto; Vischioni, Barbara; Cuccia, Francesco; Ronchi, Sara; Bonora, Maria; Riva, Giulia; Petrucci, Rachele; D'Ippolito, Emma; Mas, Francesca Dal; Preda, Lorenzo; Valvo, Francesca.
Afiliación
  • Barcellini A; National Center of Oncological Hadrontherapy (Fondazione CNAO), Pavia, Italy Amelia.Barcellini@cnao.it.
  • Vitolo V; National Center of Oncological Hadrontherapy (Fondazione CNAO), Pavia, Italy.
  • Cobianchi L; Department of Clinical-Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy.
  • Peloso A; General Surgery, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
  • Vanoli A; Division of Abdominal Surgery, Department of Surgery, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
  • Mirandola A; HepatoPancreato-Biliary Centre, Geneva University Hospitals, Geneva, Switzerland.
  • Facoetti A; Anatomic Pathology Unit, Department of Molecular Medicine, University of Pavia and Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
  • Fiore MR; National Center of Oncological Hadrontherapy (Fondazione CNAO), Pavia, Italy.
  • Iannalfi A; National Center of Oncological Hadrontherapy (Fondazione CNAO), Pavia, Italy.
  • Vischioni B; National Center of Oncological Hadrontherapy (Fondazione CNAO), Pavia, Italy.
  • Cuccia F; National Center of Oncological Hadrontherapy (Fondazione CNAO), Pavia, Italy.
  • Ronchi S; National Center of Oncological Hadrontherapy (Fondazione CNAO), Pavia, Italy.
  • Bonora M; School of Radiation Oncology, University of Palermo, Palermo, Italy.
  • Riva G; National Center of Oncological Hadrontherapy (Fondazione CNAO), Pavia, Italy.
  • Petrucci R; National Center of Oncological Hadrontherapy (Fondazione CNAO), Pavia, Italy.
  • D'Ippolito E; National Center of Oncological Hadrontherapy (Fondazione CNAO), Pavia, Italy.
  • Mas FD; National Center of Oncological Hadrontherapy (Fondazione CNAO), Pavia, Italy.
  • Preda L; National Center of Oncological Hadrontherapy (Fondazione CNAO), Pavia, Italy.
  • Valvo F; Lincoln International Business School, University of Lincoln, Lincoln, U.K.
In Vivo ; 34(3): 1547-1553, 2020.
Article en En | MEDLINE | ID: mdl-32354961
BACKGROUND/AIM: Re-irradiation of locally recurrent rectal cancer poses challenges due to the proximity of critical organs, such as the bowel. This study aimed at evaluating the safety and efficacy of re-irradiation with Carbon Ion Radiotherapy (CIRT) in rectal cancer patients with local recurrence. PATIENTS AND METHODS: Between 2014 and 2018, 14 patients were treated at the National Center of Oncological Hadrontherapy (CNAO Foundation) with CIRT for locally recurrent rectal cancer. RESULTS: All patients concluded the treatment. No G≥3 acute/late reaction nor pelvic infections were observed. The 1-year and 2-year local control rates were, 78% and 52%, respectively, and relapse occurred close to the bowel in 6 patients. The 1-year and 2-year overall survival rates were 100% and 76.2% each; while the 1-year and 2-year metastasis free survival rates were 64.3% and 43%. CONCLUSION: CIRT as re-irradiation for locally recurrent rectal cancer emerges as a safe and valid treatment with an acceptable rate of morbidity of surrounding healthy tissue.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pelvis / Neoplasias del Recto / Radioterapia de Iones Pesados / Reirradiación Tipo de estudio: Observational_studies / Prognostic_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: In Vivo Asunto de la revista: NEOPLASIAS Año: 2020 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Grecia
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pelvis / Neoplasias del Recto / Radioterapia de Iones Pesados / Reirradiación Tipo de estudio: Observational_studies / Prognostic_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: In Vivo Asunto de la revista: NEOPLASIAS Año: 2020 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Grecia