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Acute myocardial injury is common in patients with COVID-19 and impairs their prognosis.
Wei, Jia-Fu; Huang, Fang-Yang; Xiong, Tian-Yuan; Liu, Qi; Chen, Hong; Wang, Hui; Huang, He; Luo, Yi-Chun; Zhou, Xuan; Liu, Zhi-Yue; Peng, Yong; Xu, Yuan-Ning; Wang, Bo; Yang, Ying-Ying; Liang, Zong-An; Lei, Xue-Zhong; Ge, Yang; Yang, Ming; Zhang, Ling; Zeng, Ming-Quan; Yu, He; Liu, Kai; Jia, Yu-Heng; Prendergast, Bernard D; Li, Wei-Min; Chen, Mao.
Afiliación
  • Wei JF; Department of Cardiology, West China Hospital, Sichuan University, Chengdu, China.
  • Huang FY; Department of Cardiology, West China Hospital, Sichuan University, Chengdu, China.
  • Xiong TY; Department of Cardiology, West China Hospital, Sichuan University, Chengdu, China.
  • Liu Q; Department of Cardiology, West China Hospital, Sichuan University, Chengdu, China.
  • Chen H; The Public Health Clinical Center of Chengdu, Chengdu, Sichuan Province, China.
  • Wang H; Department of Cardiology, West China Hospital, Sichuan University, Chengdu, China.
  • Huang H; Department of Cardiology, West China Hospital, Sichuan University, Chengdu, China hmaochen@vip.sina.com weimi003@scu.edu.cn bernard.prendergast@gstt.nhs.uk huanghe@wchscu.cn.
  • Luo YC; Department of Radiology, West China Hospital, Sichuan University, Chengdu, China.
  • Zhou X; Department of Radiology, West China Hospital, Sichuan University, Chengdu, China.
  • Liu ZY; Department of Cardiology, West China Hospital, Sichuan University, Chengdu, China.
  • Peng Y; Department of Cardiology, West China Hospital, Sichuan University, Chengdu, China.
  • Xu YN; Department of Cardiology, West China Hospital, Sichuan University, Chengdu, China.
  • Wang B; Intensive Care Unit, West China Hospital, Sichuan University, Chengdu, China.
  • Yang YY; Department of Nephrology, West China Hospital, Sichuan University, Chengdu, China.
  • Liang ZA; Department of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, China.
  • Lei XZ; Center of Infectious Disease, West China Hospital, Sichuan University, Chengdu, China.
  • Ge Y; Department of Functional Examination Room, The Public Health Clinical Center of Chengdu, Chengdu, Sichuan Province, China.
  • Yang M; Department of Respiratory Medicine, The Public Health Clinical Center of Chengdu, Chengdu, Sichuan Province, China.
  • Zhang L; Intensive Care Unit, The Public Health Clinical Center of Chengdu, Chengdu, Sichuan Province, China.
  • Zeng MQ; Intensive Care Unit, The Public Health Clinical Center of Chengdu, Chengdu, Sichuan Province, China.
  • Yu H; Center of Infectious Disease, West China Hospital, Sichuan University, Chengdu, China.
  • Liu K; Center of Infectious Disease, West China Hospital, Sichuan University, Chengdu, China.
  • Jia YH; Department of Cardiology, West China Hospital, Sichuan University, Chengdu, China.
  • Prendergast BD; Department of Cardiology, St Thomas' Hospital, London, UK hmaochen@vip.sina.com weimi003@scu.edu.cn bernard.prendergast@gstt.nhs.uk huanghe@wchscu.cn.
  • Li WM; Department of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, China hmaochen@vip.sina.com weimi003@scu.edu.cn bernard.prendergast@gstt.nhs.uk huanghe@wchscu.cn.
  • Chen M; Department of Cardiology, West China Hospital, Sichuan University, Chengdu, China hmaochen@vip.sina.com weimi003@scu.edu.cn bernard.prendergast@gstt.nhs.uk huanghe@wchscu.cn.
Heart ; 106(15): 1154-1159, 2020 Aug.
Article en En | MEDLINE | ID: mdl-32354798
OBJECTIVE: We sought to explore the prevalence and immediate clinical implications of acute myocardial injury in a cohort of patients with COVID-19 in a region of China where medical resources are less stressed than in Wuhan (the epicentre of the pandemic). METHODS: We prospectively assessed the medical records, laboratory results, chest CT images and use of medication in a cohort of patients presenting to two designated covid-19 treatment centres in Sichuan, China. Outcomes of interest included death, admission to an intensive care unit (ICU), need for mechanical ventilation, treatment with vasoactive agents and classification of disease severity. Acute myocardial injury was defined by a value of high-sensitivity troponin T (hs-TnT) greater than the normal upper limit. RESULTS: A total of 101 cases were enrolled from January to 10 March 2020 (average age 49 years, IQR 34-62 years). Acute myocardial injury was present in 15.8% of patients, nearly half of whom had a hs-TnT value fivefold greater than the normal upper limit. Patients with acute myocardial injury were older, with a higher prevalence of pre-existing cardiovascular disease and more likely to require ICU admission (62.5% vs 24.7%, p=0.003), mechanical ventilation (43.5% vs 4.7%, p<0.001) and treatment with vasoactive agents (31.2% vs 0%, p<0.001). Log hs-TnT was associated with disease severity (OR 6.63, 95% CI 2.24 to 19.65), and all of the three deaths occurred in patients with acute myocardial injury. CONCLUSION: Acute myocardial injury is common in patients with COVID-19 and is associated with adverse prognosis.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neumonía Viral / Infecciones por Coronavirus / Troponina T / Betacoronavirus Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Humans / Middle aged País/Región como asunto: Asia Idioma: En Revista: Heart Asunto de la revista: CARDIOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neumonía Viral / Infecciones por Coronavirus / Troponina T / Betacoronavirus Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Humans / Middle aged País/Región como asunto: Asia Idioma: En Revista: Heart Asunto de la revista: CARDIOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido