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Antibacterial Activity of Amidodithiophosphonato Nickel(II) Complexes: An Experimental and Theoretical Approach.
Podda, Enrico; Arca, Massimiliano; Atzeni, Giulia; Coles, Simon J; Ibba, Antonella; Isaia, Francesco; Lippolis, Vito; Orrù, Germano; Orton, James B; Pintus, Anna; Tuveri, Enrica; Aragoni, M Carla.
Afiliación
  • Podda E; Dipartimento di Scienze Chimiche e Geologiche, Università degli Studi di Cagliari, Cittadella Universitaria, SS. 554 bivio Sestu, 09042 Monserrato-Cagliari, Italy.
  • Arca M; Dipartimento di Scienze Chimiche e Geologiche, Università degli Studi di Cagliari, Cittadella Universitaria, SS. 554 bivio Sestu, 09042 Monserrato-Cagliari, Italy.
  • Atzeni G; Dipartimento di Scienze Chimiche e Geologiche, Università degli Studi di Cagliari, Cittadella Universitaria, SS. 554 bivio Sestu, 09042 Monserrato-Cagliari, Italy.
  • Coles SJ; UK National Crystallography Service, School of Chemistry, Faculty of Engineering and Physical Sciences, University of Southampton, Southampton SO17 1BJ, UK.
  • Ibba A; Department of Surgical Sciences, University of Cagliari, 09042 Cagliari, Italy.
  • Isaia F; Dipartimento di Scienze Chimiche e Geologiche, Università degli Studi di Cagliari, Cittadella Universitaria, SS. 554 bivio Sestu, 09042 Monserrato-Cagliari, Italy.
  • Lippolis V; Dipartimento di Scienze Chimiche e Geologiche, Università degli Studi di Cagliari, Cittadella Universitaria, SS. 554 bivio Sestu, 09042 Monserrato-Cagliari, Italy.
  • Orrù G; Department of Surgical Sciences, University of Cagliari, 09042 Cagliari, Italy.
  • Orton JB; National Research Council of Italy, ISPA-CNR, 07100 Sassari, Italy.
  • Pintus A; UK National Crystallography Service, School of Chemistry, Faculty of Engineering and Physical Sciences, University of Southampton, Southampton SO17 1BJ, UK.
  • Tuveri E; Dipartimento di Scienze Chimiche e Geologiche, Università degli Studi di Cagliari, Cittadella Universitaria, SS. 554 bivio Sestu, 09042 Monserrato-Cagliari, Italy.
  • Aragoni MC; Department of Surgical Sciences, University of Cagliari, 09042 Cagliari, Italy.
Molecules ; 25(9)2020 Apr 28.
Article en En | MEDLINE | ID: mdl-32354035
The reactions of 2,4-bis(4-methoxyphenyl)-1,3-dithio-2,4-diphosphetane-2,4-disulfide (Lawesson's Reagent, LR) with benzylamine (BzNH2) and 4-phenylbutylamine (PhBuNH2) yield benzylammonium P-(4-methoxyphenyl)-N-benzyl-amidodithiophosphonate (BzNH3)(BzNH-adtp) and 4-phenylbutylammonium P-(4-methoxyphenyl)-N-(4-phenylbutyl)-amidodithiophosphonate (PhBuNH3)(PhBuNH-adtp). The relevant nickel complexes [Ni(BzNH-adtp)2] and [Ni(PhBuNH-adtp)2] and the corresponding hydrolysed derivatives (BzNH3)2[Ni(dtp)2] and (PhBuNH3)2[Ni(dtp)2] were prepared and fully characterized. The antimicrobial activity of the aforementioned amidodithiophosphonates against a set of Gram-positive and Gram-negative pathogen bacteria was evaluated, and [Ni(BzNH-adtp)2] and [Ni(PhBuNH-adtp)2] showed antiproliferative activity towards Staphylococcus aureus and Staphylococcus haemolyticus strains. density functional theory (DFT) calculations were performed to shed some light on the activity of reported compounds related to their tendency towards P-N bond cleavage.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pruebas de Sensibilidad Microbiana / Química Farmacéutica / Antibacterianos / Níquel Idioma: En Revista: Molecules Asunto de la revista: BIOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pruebas de Sensibilidad Microbiana / Química Farmacéutica / Antibacterianos / Níquel Idioma: En Revista: Molecules Asunto de la revista: BIOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Suiza