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Ceftolozane-tazobactam and ceftazidime-avibactam activity against ß-lactam-resistant Pseudomonas aeruginosa and extended-spectrum ß-lactamase-producing Enterobacterales clinical isolates from U.S. medical centres.
Hirsch, Elizabeth B; Brigman, Hunter V; Zucchi, Paola C; Chen, Alice; Anderson, Jadyn C; Eliopoulos, George M; Cheung, Nicole; Gilbertsen, Adam; Hunter, Ryan C; Emery, Christopher L; Bias, Tiffany E.
Afiliación
  • Hirsch EB; University of Minnesota College of Pharmacy, Minneapolis, MN, USA. Electronic address: ebhirsch@umn.edu.
  • Brigman HV; University of Minnesota College of Pharmacy, Minneapolis, MN, USA.
  • Zucchi PC; Northeastern University School of Pharmacy, Boston, MA, USA.
  • Chen A; Northeastern University School of Pharmacy, Boston, MA, USA.
  • Anderson JC; University of Minnesota College of Pharmacy, Minneapolis, MN, USA.
  • Eliopoulos GM; Beth Israel Deaconess Medical Center, Boston, MA, USA.
  • Cheung N; Northeastern University School of Pharmacy, Boston, MA, USA.
  • Gilbertsen A; University of Minnesota Medical School, Minneapolis, MN, USA.
  • Hunter RC; University of Minnesota Medical School, Minneapolis, MN, USA.
  • Emery CL; Indiana University School of Medicine, Indianapolis, IN, USA.
  • Bias TE; Hahnemann University Hospital, Philadelphia, PA, USA; Nabriva Therapeutics, King of Prussia, PA, USA.
J Glob Antimicrob Resist ; 22: 689-694, 2020 09.
Article en En | MEDLINE | ID: mdl-32353524
BACKGROUND: Despite availability of ceftolozane-tazobactam (C/T) and ceftazidime-avibactam (CZA) for several years, the individual spectrum of activity of each agent may not be widely known. We compared the activity of C/T and CZA against convenience samples of 119 extended-spectrum ß-lactamase (ESBL)-producing Enterobacterales and 60 ß-lactam-resistant Pseudomonas aeruginosa clinical isolates collected from three U.S. institutions. METHODS: Minimal inhibitory concentrations (MICs) for C/T and CZA were determined by broth microdilution. Molecular identification of nine ß-lactamase gene targets was conducted for Enterobacterales and P. aeruginosa isolates with increased MICs to C/T or CZA. RESULTS: More than 90% of Enterobacterales isolates demonstrated susceptibility to both C/T and CZA, in contrast to the other traditional ß-lactam agents tested, which were much less active. The MIC50/90 values were nearly equivalent between agents. The most common ß-lactamase genes identified in Enterobacterales isolates with MIC values ≥2 mg/L were the CTX-M-1 group (85%) and CMY-2-like (23%) ß-lactamases. Both agents were active against >80% of ß-lactam-resistant P. aeruginosa isolates tested, most of which had oprD mutations identified. One P. aeruginosa isolate was positive for a Klebsiella pneumoniae carbapenemase-type gene but remained meropenem-susceptible. The MIC50 values were four-fold lower in favour of C/T (1 mg/L vs. 4 mg/L) against P. aeruginosa. CONCLUSIONS: Our data suggest that either agent may be a reasonable choice for centres with a high proportion of ESBL producers; however, C/T may have improved activity against P. aeruginosa and may be preferred in institutions with a higher frequency of resistant pseudomonal isolates.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pseudomonas aeruginosa / Infecciones por Pseudomonas Límite: Humans Idioma: En Revista: J Glob Antimicrob Resist Año: 2020 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pseudomonas aeruginosa / Infecciones por Pseudomonas Límite: Humans Idioma: En Revista: J Glob Antimicrob Resist Año: 2020 Tipo del documento: Article Pais de publicación: Países Bajos