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Synthetic hybrids of six yeast species.
Peris, David; Alexander, William G; Fisher, Kaitlin J; Moriarty, Ryan V; Basuino, Mira G; Ubbelohde, Emily J; Wrobel, Russell L; Hittinger, Chris Todd.
Afiliación
  • Peris D; Laboratory of Genetics, J. F. Crow Institute for the Study of Evolution, Wisconsin Energy Institute, Center for Genomic Science Innovation, University of Wisconsin-Madison, Madison, WI, USA. david.perisnavarro@gmail.com.
  • Alexander WG; DOE Great Lakes Bioenergy Research Center, University of Wisconsin-Madison, Madison, WI, USA. david.perisnavarro@gmail.com.
  • Fisher KJ; Department of Food Biotechnology, Institute of Agrochemistry and Food Technology (IATA), CSIC, 46980, Paterna, Valencia, Spain. david.perisnavarro@gmail.com.
  • Moriarty RV; Laboratory of Genetics, J. F. Crow Institute for the Study of Evolution, Wisconsin Energy Institute, Center for Genomic Science Innovation, University of Wisconsin-Madison, Madison, WI, USA.
  • Basuino MG; DOE Great Lakes Bioenergy Research Center, University of Wisconsin-Madison, Madison, WI, USA.
  • Ubbelohde EJ; Department of Biology, Truman State University, Kirksville, MO, 63501, USA.
  • Wrobel RL; Laboratory of Genetics, J. F. Crow Institute for the Study of Evolution, Wisconsin Energy Institute, Center for Genomic Science Innovation, University of Wisconsin-Madison, Madison, WI, USA.
  • Hittinger CT; Laboratory of Genetics, J. F. Crow Institute for the Study of Evolution, Wisconsin Energy Institute, Center for Genomic Science Innovation, University of Wisconsin-Madison, Madison, WI, USA.
Nat Commun ; 11(1): 2085, 2020 04 29.
Article en En | MEDLINE | ID: mdl-32350251
Allopolyploidy generates diversity by increasing the number of copies and sources of chromosomes. Many of the best-known evolutionary radiations, crops, and industrial organisms are ancient or recent allopolyploids. Allopolyploidy promotes differentiation and facilitates adaptation to new environments, but the tools to test its limits are lacking. Here we develop an iterative method of Hybrid Production (iHyPr) to combine the genomes of multiple budding yeast species, generating Saccharomyces allopolyploids of at least six species. When making synthetic hybrids, chromosomal instability and cell size increase dramatically as additional copies of the genome are added. The six-species hybrids initially grow slowly, but they rapidly regain fitness and adapt, even as they retain traits from multiple species. These new synthetic yeast hybrids and the iHyPr method have potential applications for the study of polyploidy, genome stability, chromosome segregation, and bioenergy.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Saccharomyces / Hibridación Genética Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Saccharomyces / Hibridación Genética Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido