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Polarimetric second-harmonic generation microscopy of the hierarchical structure of collagen in stage I-III non-small cell lung carcinoma.
Golaraei, Ahmad; Mostaço-Guidolin, Leila B; Raja, Vaishnavi; Navab, Roya; Wang, Tao; Sakashita, Shingo; Yasufuku, Kazuhiro; Tsao, Ming-Sound; Wilson, Brian C; Barzda, Virginijus.
Afiliación
  • Golaraei A; Department of Physics, University of Toronto, 60 St. George St, Toronto, M5S 1A7, Canada.
  • Mostaço-Guidolin LB; Department of Chemical and Physical Sciences, University of Toronto Mississauga, 3359 Mississauga Rd North, Mississauga, L5L 1C6, Canada.
  • Raja V; Princess Margaret Cancer Centre, University Health Network, 101 College St, Toronto, M5G 1L7, Canada.
  • Navab R; Department of Systems and Computer Engineering, Faculty of Engineering and Design, Carleton University, 1125 Colonel By Drive, Ottawa, K1S 5B6, Canada.
  • Wang T; Department of Chemistry, University of Western Ontario, 1151 Richmond St, London, N6A 3K7, Canada.
  • Sakashita S; Princess Margaret Cancer Centre, University Health Network, 101 College St, Toronto, M5G 1L7, Canada.
  • Yasufuku K; Department of Pathology and Molecular Medicine, Queen's University, 88 Stuart St, Kingston, K7L 3N6, Canada.
  • Tsao MS; Princess Margaret Cancer Centre, University Health Network, 101 College St, Toronto, M5G 1L7, Canada.
  • Wilson BC; Princess Margaret Cancer Centre, University Health Network, 101 College St, Toronto, M5G 1L7, Canada.
  • Barzda V; Toronto General Hospital, University Health Network, 200 Elizabeth St, Toronto, M5G 2C4, Canada.
Biomed Opt Express ; 11(4): 1851-1863, 2020 Apr 01.
Article en En | MEDLINE | ID: mdl-32341852
Polarimetric second-harmonic generation (P-SHG) microscopy is used to quantify the structural alteration of collagen in stage-I,-II and -III non-small cell lung carcinoma (NSCLC) ex vivo tissue. The achiral and chiral molecular second-order susceptibility tensor components ratios (R and C, respectively), the degree of linear polarization (DLP) and the in-plane collagen fiber orientation (δ) were extracted. Further, texture analysis was performed on the SHG intensity, R, C, DLP and δ. The distributions of R, C, DLP and δ as well as the textural features of entropy, correlation and contrast show significant differences between normal and tumor tissues.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Biomed Opt Express Año: 2020 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Biomed Opt Express Año: 2020 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Estados Unidos