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Perinatal fluoxetine treatment and dams' early life stress history alter affective behavior in rat offspring depending on serotonin transporter genotype and sex.
Houwing, Danielle J; Schuttel, Kirsten; Struik, Eline L; Arling, Chantal; Ramsteijn, Anouschka S; Heinla, I; Olivier, Jocelien D A.
Afiliación
  • Houwing DJ; Department of Neurobiology, GELIFES, University of Groningen, Nijenborgh 7, 9747 AG Groningen, The Netherlands.
  • Schuttel K; Department of Neurobiology, GELIFES, University of Groningen, Nijenborgh 7, 9747 AG Groningen, The Netherlands.
  • Struik EL; Department of Neurobiology, GELIFES, University of Groningen, Nijenborgh 7, 9747 AG Groningen, The Netherlands.
  • Arling C; Department of Neurobiology, GELIFES, University of Groningen, Nijenborgh 7, 9747 AG Groningen, The Netherlands.
  • Ramsteijn AS; Department of Neurobiology, GELIFES, University of Groningen, Nijenborgh 7, 9747 AG Groningen, The Netherlands.
  • Heinla I; Department of Psychology, UiT The Arctic University of Norway, Hansine Hansens veg 18, 9019 Tromsø, Norway.
  • Olivier JDA; Department of Neurobiology, GELIFES, University of Groningen, Nijenborgh 7, 9747 AG Groningen, The Netherlands. Electronic address: j.d.a.oliver@rug.nl.
Behav Brain Res ; 392: 112657, 2020 08 17.
Article en En | MEDLINE | ID: mdl-32339551
Many women diagnosed with a major depression continue or initiate antidepressant treatment during pregnancy. Both maternal stress and selective serotonin inhibitor (SSRI) antidepressant treatment during pregnancy have been associated with changes in offspring behavior, including increased anxiety and depressive-like behavior. Our aim was to investigate the effects of the SSRI fluoxetine (FLX), with and without the presence of a maternal depression, on affective behavior in male and female rat offspring. As reduced serotonin transporter (SERT) availability has been associated with altered behavioral outcome, both offspring with normal (SERT+/+) and reduced (SERT+/-) SERT expression were included. For our animal model of maternal depression, SERT+/- dams exposed to early life stress were used. Perinatal FLX treatment and early life stress in dams (ELSD) had sex- and genotype-specific effects on affective behavior in the offspring. In female offspring, perinatal FLX exposure interacted with SERT genotype to increase anxiety and depressive-like behavior in SERT+/+, but not SERT+/-, females. In male offspring, ELSD reduced anxiety and interacted with SERT genotype to decrease depressive-like behavior in SERT+/-, but not SERT+/+, males. Altogether, SERT+/+ female offspring appear to be more sensitive than SERT+/- females to the effects of perinatal FLX exposure, while SERT+/- male offspring appear more sensitive than SERT+/+ males to the effects of ELSD on affective behavior. Our data suggest a role for offspring SERT genotype and sex in FLX and ELSD-induced effects on affective behavior, thereby contributing to our understanding of the effects of perinatal SSRI treatment on offspring behavior later in life.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Estrés Psicológico / Fluoxetina / Afecto / Proteínas de Transporte de Serotonina en la Membrana Plasmática Tipo de estudio: Prognostic_studies Límite: Animals / Pregnancy Idioma: En Revista: Behav Brain Res Año: 2020 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Estrés Psicológico / Fluoxetina / Afecto / Proteínas de Transporte de Serotonina en la Membrana Plasmática Tipo de estudio: Prognostic_studies Límite: Animals / Pregnancy Idioma: En Revista: Behav Brain Res Año: 2020 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Países Bajos