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Intraoperative use of optical coherence tomography to differentiate normal and diseased thyroid and parathyroid tissues from lymph node and fat.
Rubinstein, Marc; Hu, Allison C; Chung, Phil-Sang; Kim, Jason H; Osann, Kathryn E; Schalch, Paul; Armstrong, William B; Wong, Brian J F.
Afiliación
  • Rubinstein M; Departement of Otolaryngology - Head and Neck Surgery, University of California Irvine, Orange, CA, USA.
  • Hu AC; Beckman Laser Institute and Medical Clinic, University of California Irvine, 1002 Health Sciences Rd, Irvine, CA, 92617, USA.
  • Chung PS; Departement of Otolaryngology - Head and Neck Surgery, University of California Irvine, Orange, CA, USA.
  • Kim JH; Beckman Laser Institute and Medical Clinic, University of California Irvine, 1002 Health Sciences Rd, Irvine, CA, 92617, USA.
  • Osann KE; Department of Biomedical Engineering, University of California Irvine, Irvine, CA, USA.
  • Schalch P; Beckman Laser Institute Korea, Dankook University, Cheonan, South Korea.
  • Armstrong WB; Department of Otolaryngology - Head and Neck Surgery, College of Medicine, Dankook University, Cheonan, South Korea.
  • Wong BJF; Departement of Otolaryngology - Head and Neck Surgery, University of California Irvine, Orange, CA, USA.
Lasers Med Sci ; 36(2): 269-278, 2021 Mar.
Article en En | MEDLINE | ID: mdl-32337680
The purpose of this study is twofold: (1) to determine the feasibility of optical coherence tomography (OCT) to differentiate normal and diseased tissue of the neck region intraoperatively and (2) to evaluate how accurately a cohort of test subjects can identify various tissue types when shown a sample set of OCT images. In this in vivo, prospective, single institutional study, an OCT imaging system (Niris, Imalux, Cleveland, OH) was used to image parathyroid, thyroid, lymph node, and fat tissue in 76 patients during neck surgery. Biopsies were performed for comparison of OCT images with histology in select cases (n = 20). Finally, a group of either surgeons or scientists familiar with OCT (n = 17) were shown a sample of OCT images and asked to identify the tissue. A total of 437 OCT images were analyzed, and characteristic features of each tissue type were identified. OCT demonstrated distinct differences in structural architecture and signal intensity that allows differentiation between thyroid and parathyroid tissues, lymph nodes, and fat. OCT images were also compared with histology with good correlation. There was no difference in correctly identifying OCT-imaged tissue type between surgeons and scientists. This study is the first in vivo OCT imaging study to evaluate both normal and diseased tissues that may be encountered during neck surgery. OCT has the potential to become a valuable intraoperative tool to differentiate diseased and normal thyroid tissue intraoperatively to obtain an "optical biopsy" in real time without fixation, staining, or tissue resection.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Glándulas Paratiroides / Glándula Tiroides / Tejido Adiposo / Tomografía de Coherencia Óptica / Ganglios Linfáticos Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Lasers Med Sci Asunto de la revista: BIOTECNOLOGIA / RADIOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Glándulas Paratiroides / Glándula Tiroides / Tejido Adiposo / Tomografía de Coherencia Óptica / Ganglios Linfáticos Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Lasers Med Sci Asunto de la revista: BIOTECNOLOGIA / RADIOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido