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Use of the kinetically-derived maximum dose concept in selection of top doses for toxicity studies hampers proper hazard assessment and risk management.
Heringa, Minne B; Cnubben, Nicole H P; Slob, Wout; Pronk, Marja E J; Muller, Andre; Woutersen, Marjolijn; Hakkert, Betty C.
Afiliación
  • Heringa MB; National Institute for Public Health and the Environment (RIVM), Centre for Safety of Substances and Products (VSP), Bilthoven, the Netherlands.
  • Cnubben NHP; National Institute for Public Health and the Environment (RIVM), Centre for Safety of Substances and Products (VSP), Bilthoven, the Netherlands.
  • Slob W; National Institute for Public Health and the Environment (RIVM), Centre for Safety of Substances and Products (VSP), Bilthoven, the Netherlands.
  • Pronk MEJ; National Institute for Public Health and the Environment (RIVM), Centre for Safety of Substances and Products (VSP), Bilthoven, the Netherlands.
  • Muller A; National Institute for Public Health and the Environment (RIVM), Centre for Safety of Substances and Products (VSP), Bilthoven, the Netherlands.
  • Woutersen M; National Institute for Public Health and the Environment (RIVM), Centre for Safety of Substances and Products (VSP), Bilthoven, the Netherlands. Electronic address: Marjolijn.woutersen@rivm.nl.
  • Hakkert BC; National Institute for Public Health and the Environment (RIVM), Centre for Safety of Substances and Products (VSP), Bilthoven, the Netherlands.
Regul Toxicol Pharmacol ; 114: 104659, 2020 Jul.
Article en En | MEDLINE | ID: mdl-32334038
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sustancias Peligrosas / Pruebas de Toxicidad Tipo de estudio: Etiology_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Regul Toxicol Pharmacol Año: 2020 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sustancias Peligrosas / Pruebas de Toxicidad Tipo de estudio: Etiology_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Regul Toxicol Pharmacol Año: 2020 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Países Bajos