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Gender Predilection in Sporadic Parathyroid Adenomas.
Yavropoulou, Maria P; Anastasilakis, Athanasios D; Panagiotakou, Argyro; Kassi, Evanthia; Makras, Polyzois.
Afiliación
  • Yavropoulou MP; Endocrinology Unit, 1st Department of Propaedeutic Internal Medicine, Medicine School, National and Kapodistrian University of Athens, 11527 Athens, Greece.
  • Anastasilakis AD; Department of Endocrinology, 424 General Military Hospital, 56429 Thessaloniki, Greece.
  • Panagiotakou A; Endocrinology Unit, 1st Department of Propaedeutic Internal Medicine, Medicine School, National and Kapodistrian University of Athens, 11527 Athens, Greece.
  • Kassi E; Endocrinology Unit, 1st Department of Propaedeutic Internal Medicine, Medicine School, National and Kapodistrian University of Athens, 11527 Athens, Greece.
  • Makras P; Department of Biological Chemistry, National and Kapodistrian University of Athens, 11527 Athens, Greece.
Int J Mol Sci ; 21(8)2020 Apr 22.
Article en En | MEDLINE | ID: mdl-32331456
Primary hyperparathyroidism is a common endocrinopathy that is mainly caused by benign parathyroid adenomas. The frequency, clinical presentation and complications of the disease show significant differences between genders, with the majority of cases being reported in postmenopausal women. Due to this gender predilection, several studies have investigated the role of sex hormones in the pathogenesis of the disease and their potential use as targets for optimal and gender-specific management. Epigenetic mechanisms that regulate gene transcription may also contribute to these differences between genders. In this review, we outline what is currently known regarding the role of sex hormones and the recent data on the role of non-coding RNAs in the differences between genders in primary hyperparathyroidism due to sporadic parathyroid adenomas.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de las Paratiroides Tipo de estudio: Prevalence_studies / Risk_factors_studies Aspecto: Determinantes_sociais_saude Límite: Female / Humans / Male Idioma: En Revista: Int J Mol Sci Año: 2020 Tipo del documento: Article País de afiliación: Grecia Pais de publicación: Suiza

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de las Paratiroides Tipo de estudio: Prevalence_studies / Risk_factors_studies Aspecto: Determinantes_sociais_saude Límite: Female / Humans / Male Idioma: En Revista: Int J Mol Sci Año: 2020 Tipo del documento: Article País de afiliación: Grecia Pais de publicación: Suiza