Your browser doesn't support javascript.
loading
Comprehensive Analysis of Adverse Events Associated with Gastric Peroral Endoscopic Myotomy: An International Multicenter Study.
Ichkhanian, Y; Vosoughi, K; Aghaie Meybodi, M; Jacques, J; Sethi, A; Patel, A A; Aadam, A A; Triggs, J R; Bapaye, A; Dorwat, S; Benias, P; Chaves, D M; Barret, M; Law, R J; Browers, N; Pioche, M; Draganov, P V; Kotzev, A; Estremera, F; Albeniz, E; Ujiki, M B; Callahan, Z M; Itani, M I; Brewer, O G; Khashab, M A.
Afiliación
  • Ichkhanian Y; Division of Gastroenterology and Hepatology, Johns Hopkins Medical Institution, Baltimore, MD, USA.
  • Vosoughi K; Division of Gastroenterology and Hepatology, Johns Hopkins Medical Institution, Baltimore, MD, USA.
  • Aghaie Meybodi M; Division of Gastroenterology and Hepatology, Johns Hopkins Medical Institution, Baltimore, MD, USA.
  • Jacques J; Gastroenterology Department, Limoges University Hospital, 2 Avenue Martin Luther King, 87042, Rouen, France.
  • Sethi A; Division of Digestive and Liver Diseases, Columbia University Medical Center, New York, NY, USA.
  • Patel AA; Division of Digestive and Liver Diseases, Columbia University Medical Center, New York, NY, USA.
  • Aadam AA; Division of Gastroenterology and Hepatology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
  • Triggs JR; Division of Gastroenterology and Hepatology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
  • Bapaye A; Department of Digestive Diseases & Endoscopy, Deenanath Mangeshkar Hospital and Research Center, Pune, Maharashtra, India.
  • Dorwat S; Department of Digestive Diseases & Endoscopy, Deenanath Mangeshkar Hospital and Research Center, Pune, Maharashtra, India.
  • Benias P; Division of Gastroenterology, Zucker School of Medicine at Hofstra/Northwell, Long Island Jewish Medical Center, Northwell Health System, New Hyde Park, NY, USA.
  • Chaves DM; Gastroenterologia, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil.
  • Barret M; Gastroenterology Unit, Cochin University Hospital, Université Paris Descartes, Paris, France.
  • Law RJ; Unité INSERM U1016, Université Paris Descartes, Sorbonne Paris Cité, Paris, France.
  • Browers N; University of Michigan Health Care System, Ann Arbor, USA.
  • Pioche M; University of Michigan Health Care System, Ann Arbor, USA.
  • Draganov PV; Service d'Hépato-gastro-entérologie, Hôpital Edouard Herriot, CHU Lyon, Lyon, France.
  • Kotzev A; Division of Gastroenterology, Hepatology and Nutrition, University of Florida, Gainesville, FL, USA.
  • Estremera F; Clinic of Gastroenterology, University Hospital "Alexandrovska", Sofia, Bulgaria.
  • Albeniz E; Clinic of Gastroenterology, University Hospital "Alexandrovska", Sofia, Bulgaria.
  • Ujiki MB; Division of Gastroenterology, Complejo Hospitalario de Navarra, Pamplona, Spain.
  • Callahan ZM; Section of Minimally Invasive Surgery, Department of Surgery, NorthShore University Health System, Evanston, IL, USA.
  • Itani MI; Section of Minimally Invasive Surgery, Department of Surgery, NorthShore University Health System, Evanston, IL, USA.
  • Brewer OG; Division of Gastroenterology and Hepatology, Johns Hopkins Medical Institution, Baltimore, MD, USA.
  • Khashab MA; Division of Gastroenterology and Hepatology, Johns Hopkins Medical Institution, Baltimore, MD, USA.
Surg Endosc ; 35(4): 1755-1764, 2021 04.
Article en En | MEDLINE | ID: mdl-32328824
BACKGROUND: Gastric peroral endoscopic myotomy (G-POEM) has emerged as an effective management approach for patients with refractory gastroparesis. This study aims to comprehensively study the safety of G-POEM and describe the predictive factors of adverse events (AEs) occurrence. METHODS: This study is a retrospective study involving 13 tertiary care centers (7 USA, 1 South America, 4 Europe, and 1 Asia). Patients who underwent G-POEM for refractory gastroparesis were included. Cases were identified by the occurrence of AEs. For each case, two controls were randomly selected and matched for age (± 10 years), gender, and etiology of gastroparesis. RESULTS: A total of 216 patients underwent G-POEM for gastroparesis. Overall, 31 (14%) AEs were encountered [mild 24 (77%), moderate 5 (16%), and severe 2 (6%)] during the duration of the study. The most common AE was abdominal pain (n = 16), followed by mucosotomy (n = 5) and capnoperitoneum (n = 4), and AEs were most commonly identified within the first 48-h post-procedure 18 (58%). The risk of adverse event occurrence was significantly higher for endoscopists with experience of < 20 G-POEM procedures (OR 3.03 [1.03-8.94], p < 0.05). CONCLUSION: G-POEM seems to be a safe intervention for refractory gastroparesis. AEs are most commonly mild and managed conservatively. Longitudinal mucosal incision, use of hook knife, use of clips for mucosal closure and endoscopist's experience with > 20 G-POEM procedures is significantly associated with decreased incidence of AEs.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Internacionalidad / Piloromiotomia Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Surg Endosc Asunto de la revista: DIAGNOSTICO POR IMAGEM / GASTROENTEROLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Alemania
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Internacionalidad / Piloromiotomia Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Surg Endosc Asunto de la revista: DIAGNOSTICO POR IMAGEM / GASTROENTEROLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Alemania