Your browser doesn't support javascript.
loading
Dynamics of immunoglobulin G subclasses during the first two years of life in Malawian infants born to HIV-positive mothers.
Baroncelli, Silvia; Galluzzo, Clementina Maria; Liotta, Giuseppe; Andreotti, Mauro; Orlando, Stefano; Ciccacci, Fausto; Jere, Haswell; Luhanga, Richard; Sagno, Jean Baptiste; Amici, Roberta; Marazzi, Maria Cristina; Giuliano, Marina.
Afiliación
  • Baroncelli S; National Center for Global Health, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161, Rome, Italy. silvia.baroncelli@iss.it.
  • Galluzzo CM; National Center for Global Health, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161, Rome, Italy.
  • Liotta G; Department of Biomedicine and Preventio, University of Rome Tor Vergata, Rome, Italy.
  • Andreotti M; National Center for Global Health, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161, Rome, Italy.
  • Orlando S; Department of Biomedicine and Preventio, University of Rome Tor Vergata, Rome, Italy.
  • Ciccacci F; Saint Camillus International University of Health Sciences, Rome, Italy.
  • Jere H; DREAM Program, Community of S. Egidio, Blantyre, Malawi.
  • Luhanga R; DREAM Program, Community of S. Egidio, Blantyre, Malawi.
  • Sagno JB; DREAM Program, Community of S. Egidio, Blantyre, Malawi.
  • Amici R; National Center for Global Health, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161, Rome, Italy.
  • Marazzi MC; Department of Human Sciences, LUMSA University, Rome, Italy.
  • Giuliano M; National Center for Global Health, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161, Rome, Italy.
BMC Pediatr ; 20(1): 181, 2020 04 23.
Article en En | MEDLINE | ID: mdl-32326903
BACKGROUND: Maternal antibodies are key components of the protective responses of infants who are unable to produce their own IgG until 6 months of life. There is evidence that HIV-exposed uninfected children (HEU) have IgG levels abnormalities, that can be partially responsible for the higher vulnerability to infections in the first 2 years of the life of this population. This retrospective study aimed to characterize the dynamics in plasma levels of total IgG and their isotypes during the first 2 years of life in HEU infants exclusively breastfed through 6 months of age. METHODS: Total IgG, IgG1, IgG2, IgG3 and IgG4 isotypes, and IgM and IgA plasma concentrations were determined by nephelometric methods in 30 Malawian infants born to HIV-positive women at month 1, 6 and 24 of life. RESULTS: At 1-month infants had a median concentration of total IgG of 8.48 g/l, (IQR 7.57-9.15), with an overrepresentation of the IgG1 isotype (89.0% of total) and low levels of IgG2 (0.52 g/l, IQR, 0.46-0.65). Total IgG and IgG1 concentrations were lower at 6 months (- 2.1 and - 1.12 g/dl, respectively) reflecting disappearance of maternal antibodies, but at 24 months their levels were higher with respect to the reported reference values for age-matched pairs. Abnormal isotype distribution was still present at 24 months with IgG2 remaining strongly underrepresented (0.87 g/l, 7.5% of total IgG). CONCLUSION: HIV exposure during pregnancy and breastfeeding seems to influence the IgG maturation and isotype distribution that persist in 2-year old infants.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Inmunoglobulina G / Infecciones por VIH Tipo de estudio: Observational_studies Límite: Child / Child, preschool / Female / Humans / Infant / Pregnancy Idioma: En Revista: BMC Pediatr Asunto de la revista: PEDIATRIA Año: 2020 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Inmunoglobulina G / Infecciones por VIH Tipo de estudio: Observational_studies Límite: Child / Child, preschool / Female / Humans / Infant / Pregnancy Idioma: En Revista: BMC Pediatr Asunto de la revista: PEDIATRIA Año: 2020 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Reino Unido