Aberrant TRPM4 expression in MLL-rearranged acute myeloid leukemia and its blockade induces cell cycle arrest via AKT/GLI1/Cyclin D1 pathway.

Wang, Fujue; Wu, Pengqiang; Gong, Shuaige; Chen, Yingying; Gao, Jie; Wang, Shuoting; Shen, Qianqing; Tao, Huan; Hua, Fang; Zhou, ZhenCang; Zou, Zhongqing; Ma, Tao; Jia, Yongqian

Wang, Fujue; Wu, Pengqiang; Gong, Shuaige; Chen, Yingying; Gao, Jie; Wang, Shuoting; Shen, Qianqing; Tao, Huan; Hua, Fang; Zhou, ZhenCang; Zou, Zhongqing; Ma, Tao; Jia, Yongqian.

Afiliación

Wang F; Department of Hematology and Research Laboratory of Hematology, West China Hospital of Sichuan University, #37 Guoxue Alley, Wuhou District, Chengdu 610041, Sichuan, China.
Wu P; Department of Hematology and Research Laboratory of Hematology, West China Hospital of Sichuan University, #37 Guoxue Alley, Wuhou District, Chengdu 610041, Sichuan, China; Department of Hematology, The first affiliated hospital of Southwest Medical University, Luzhou 646000, Sichuan, China.
Gong S; Department of Hematology and Research Laboratory of Hematology, West China Hospital of Sichuan University, #37 Guoxue Alley, Wuhou District, Chengdu 610041, Sichuan, China.
Chen Y; Department of Hematology and Research Laboratory of Hematology, West China Hospital of Sichuan University, #37 Guoxue Alley, Wuhou District, Chengdu 610041, Sichuan, China.
Gao J; Department of Hematology and Research Laboratory of Hematology, West China Hospital of Sichuan University, #37 Guoxue Alley, Wuhou District, Chengdu 610041, Sichuan, China.
Wang S; Department of Hematology and Research Laboratory of Hematology, West China Hospital of Sichuan University, #37 Guoxue Alley, Wuhou District, Chengdu 610041, Sichuan, China.
Shen Q; Department of Hematology and Research Laboratory of Hematology, West China Hospital of Sichuan University, #37 Guoxue Alley, Wuhou District, Chengdu 610041, Sichuan, China.
Tao H; Department of Hematology and Research Laboratory of Hematology, West China Hospital of Sichuan University, #37 Guoxue Alley, Wuhou District, Chengdu 610041, Sichuan, China.
Hua F; Department of Hematology and Research Laboratory of Hematology, West China Hospital of Sichuan University, #37 Guoxue Alley, Wuhou District, Chengdu 610041, Sichuan, China; Department of Hematology, Zigong First People's Hospital, Zigong 643000, Sichuan, China.
Zhou Z; Department of Hematology and Research Laboratory of Hematology, West China Hospital of Sichuan University, #37 Guoxue Alley, Wuhou District, Chengdu 610041, Sichuan, China.
Zou Z; Department of Hematology and Research Laboratory of Hematology, West China Hospital of Sichuan University, #37 Guoxue Alley, Wuhou District, Chengdu 610041, Sichuan, China; Department of Hematology, The first affiliated hospital of Chengdu Medical College, Chengdu 610041, Sichuan, China.
Ma T; Department of Hematology, The first affiliated hospital of Southwest Medical University, Luzhou 646000, Sichuan, China.
Jia Y; Department of Hematology and Research Laboratory of Hematology, West China Hospital of Sichuan University, #37 Guoxue Alley, Wuhou District, Chengdu 610041, Sichuan, China. Electronic address: jia_yq@scu.edu.cn.

Cell Signal ; 72: 109643, 2020 08.

Article en En | MEDLINE | ID: mdl-32320859

Asunto(s)

Puntos de Control del Ciclo Celular/genética; Ciclina D1/metabolismo; Reordenamiento Génico/genética; N-Metiltransferasa de Histona-Lisina/genética; Leucemia Mieloide Aguda/genética; Proteína de la Leucemia Mieloide-Linfoide/genética; Proteínas Proto-Oncogénicas c-akt/metabolismo; Canales Catiónicos TRPM/genética; Proteína con Dedos de Zinc GLI1/metabolismo; Adulto; Estudios de Casos y Controles; Ciclo Celular/genética; Línea Celular Tumoral; Proliferación Celular/genética; Femenino; Regulación Neoplásica de la Expresión Génica; N-Metiltransferasa de Histona-Lisina/metabolismo; Proteínas de Homeodominio/metabolismo; Humanos; Leucemia Mieloide Aguda/patología; Masculino; Persona de Mediana Edad; Proteína de la Leucemia Mieloide-Linfoide/metabolismo; Regiones Promotoras Genéticas/genética; Transducción de Señal; Canales Catiónicos TRPM/metabolismo; Transcripción Genética; Regulación hacia Arriba/genética

Palabras clave

Acute myeloid leukemia; HOXA9; MLL; TRPM4

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Reordenamiento Génico / Leucemia Mieloide Aguda / N-Metiltransferasa de Histona-Lisina / Ciclina D1 / Proteínas Proto-Oncogénicas c-akt / Canales Catiónicos TRPM / Proteína de la Leucemia Mieloide-Linfoide / Puntos de Control del Ciclo Celular / Proteína con Dedos de Zinc GLI1 Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Cell Signal Año: 2020 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google