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Pathological myopia-induced antioxidative proteins in the vitreous humor.
Wei, Qiaoling; Zhang, Ting; Fan, Jiawen; Jiang, Rui; Chang, Qing; Hong, Jin; Xu, Gezhi.
Afiliación
  • Wei Q; Ophthalmology Department, EYE & ENT Hospital of Fudan University, Shanghai 200031, China.
  • Zhang T; Key Laboratory of Visual Impairment and Restoration of Fudan University, Shanghai 200031, China.
  • Fan J; Ophthalmology Department, EYE & ENT Hospital of Fudan University, Shanghai 200031, China.
  • Jiang R; Key Laboratory of Visual Impairment and Restoration of Fudan University, Shanghai 200031, China.
  • Chang Q; Ophthalmology Department, EYE & ENT Hospital of Fudan University, Shanghai 200031, China.
  • Hong J; Key Laboratory of Visual Impairment and Restoration of Fudan University, Shanghai 200031, China.
  • Xu G; Ophthalmology Department, EYE & ENT Hospital of Fudan University, Shanghai 200031, China.
Ann Transl Med ; 8(5): 193, 2020 Mar.
Article en En | MEDLINE | ID: mdl-32309340
BACKGROUND: This study aimed to investigate differentially expressed proteins in the vitreous humor (VH) of pathological myopia (PM) and normal eyes. METHODS: VH samples were collected from patients undergoing surgical treatment for rhegmatogenous retinal detachment (RRD), idiopathic epiretinal membrane (ERM), myopic retinoschisis (MRS) or macular hole (MH). A label-free quantitative proteomic analysis was performed to detect the differentially expressed proteins, and expression of three differentially expressed proteins was confirmed by ELISA. RESULTS: In PM patients (MH-PM, MRS-PM and RRD-PM), the expression of prostaglandin-H2 D-isomerase (PGDS) and glutathione peroxidase 3 (GPX3) was significantly lower than in controls (MH, ERM, and RRD). The versican core protein expression decreased in the PM group. The vitreous concentrations of PGDS and GPX3 in patients with axial length (AL) of 26.5-29.0 mm were higher than in patients with AL >29.0 mm or AL <26.5 mm. NRF-2 expression was the lowest in patients with AL >29.0 mm. CONCLUSIONS: Our study provides new evidence on the molecular changes in the VH of PM patients, and these molecules have the potential to become new targets for the therapy of PM.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Ann Transl Med Año: 2020 Tipo del documento: Article País de afiliación: China Pais de publicación: China
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Ann Transl Med Año: 2020 Tipo del documento: Article País de afiliación: China Pais de publicación: China