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Metal ion-responsive nanocarrier derived from phosphonated calix[4]arenes for delivering dauricine specifically to sites of brain injury in a mouse model of intracerebral hemorrhage.
Li, Mingxin; Liu, Guohao; Wang, Kaixuan; Wang, Lingfeng; Fu, Xiang; Lim, Lee Yong; Chen, Wei; Mo, Jingxin.
Afiliación
  • Li M; Clinical Research Center for Neurological Diseases of Guangxi Province, The Affiliated Hospital of Guilin Medical University, Guilin, 541001, China.
  • Liu G; School of Pharmacy, Guilin Medical University, Guilin, 541001, China.
  • Wang K; Clinical Research Center for Neurological Diseases of Guangxi Province, The Affiliated Hospital of Guilin Medical University, Guilin, 541001, China.
  • Wang L; Department of Radiology, Affiliated Hospital of Jilin Medical University, Jilin, 132013, China.
  • Fu X; Clinical Research Center for Neurological Diseases of Guangxi Province, The Affiliated Hospital of Guilin Medical University, Guilin, 541001, China.
  • Lim LY; School of Pharmacy, Guilin Medical University, Guilin, 541001, China.
  • Chen W; Clinical Research Center for Neurological Diseases of Guangxi Province, The Affiliated Hospital of Guilin Medical University, Guilin, 541001, China.
  • Mo J; School of Pharmacy, Guilin Medical University, Guilin, 541001, China.
J Nanobiotechnology ; 18(1): 61, 2020 Apr 19.
Article en En | MEDLINE | ID: mdl-32306970
Primary intracerebral hemorrhage (ICH) is a leading cause of long-term disability and death worldwide. Drug delivery vehicles to treat ICH are less than satisfactory because of their short circulation lives, lack of specific targeting to the hemorrhagic site, and poor control of drug release. To exploit the fact that metal ions such as Fe2+ are more abundant in peri-hematomal tissue than in healthy tissue because of red blood cell lysis, we developed a metal ion-responsive nanocarrier based on a phosphonated calix[4]arene derivative in order to deliver the neuroprotective agent dauricine (DRC) specifically to sites of primary and secondary brain injury. The potential of the dauricine-loaded nanocarriers for ICH therapy was systematically evaluated in vitro and in mouse models of autologous whole blood double infusion. The nanocarriers significantly reduced brain water content, restored blood-brain barrier integrity and attenuated neurological deficits by inhibiting the activation of glial cells, infiltration by neutrophils as well as production of pro-inflammatory factors (IL-1ß, IL-6, TNF-α) and matrix-metalloprotease-9. These results suggest that our dauricine-loaded nanocarriers can improve neurological outcomes in an animal model of ICH by reducing inflammatory injury and inhibiting apoptosis and ferroptosis.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fenoles / Portadores de Fármacos / Hemorragia Cerebral / Fármacos Neuroprotectores / Bencilisoquinolinas / Tetrahidroisoquinolinas / Calixarenos / Nanoestructuras / Metales Tipo de estudio: Prognostic_studies Límite: Animals / Humans / Male Idioma: En Revista: J Nanobiotechnology Año: 2020 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fenoles / Portadores de Fármacos / Hemorragia Cerebral / Fármacos Neuroprotectores / Bencilisoquinolinas / Tetrahidroisoquinolinas / Calixarenos / Nanoestructuras / Metales Tipo de estudio: Prognostic_studies Límite: Animals / Humans / Male Idioma: En Revista: J Nanobiotechnology Año: 2020 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido